Recombinant Rat Sodium/iodide cotransporter (Slc5a5), partial

1. Nis expression is controlled by Txn/Ape1 through a TSH/selenium-dependent mechanism. PMID: 26650895
2. excess iodide transcriptionally represses NIS gene expression through the impairment of Pax8 and p65 transcriptional activity. PMID: 26872612
3. Report sodium binding date for NIS, where transporter activity is electrogenic, with a 2:1 Na(+)/I(-) transport stoichiometry. PMID: 26009546
4. Although the affinity of NIS for I- is low, it increases when Na+ is bound. NIS takes advantage of the extracellular Na+ concentration and the pronounced increase in its own affinity for I- and for the second Na+ elicited by binding of the first. PMID: 24888603
5. It is feasible to use lentiviral vectors to deliver sodium iodide symporter (NIS) gene for the non-invasive monitoring of bone marrowderived mesenchymal stem cell transplantation and survival in the infarcted myocardium in vivo. PMID: 25319483
6. sodium/iodide symporter expression is inhibited by iodide excess in a process involving the PI3K/Akt signaling pathway PMID: 24424051
7. Molecular imaging of luciferase signal and sodium-iodide symporter imaging may be useful for in vivo optimization of bioenergetics in transplanted cells. PMID: 23255420
8. Overexpression of p38beta or Rac1 significantly enhanced (1.9- and 3.9-fold, respectively), the tRA-stimulated NIS expression in MCF-7 cells. PMID: 22157753
9. This study found that KT5823 decreases iodide uptake within 0.5 h of treatment in trans-retinoic acid and hydrocortisone-treated MCF-7 breast cancer cells, but increases iodide uptake in thyroid cells. PMID: 21209020
10. A physical interaction was observed between the NF-kappaB p65 subunit and paired box 8 (Pax8), which appears to be responsible for the synergic effect displayed by these transcription factors on NIS gene transcription. PMID: 20667985
11. Data show for the first time that iodide regulates sodium-iodide symporter mRNA expression at the posttranscriptional level, providing a new mechanism by which iodide exerts its autoregulatory effect on thyroid. PMID: 20107044
12. PI3K is involved in the IGF-I inhibition of TSH-induced sodium/iodide symporter gene expression PMID: 11818505
13. an uncharged amino acid residue with a small side chain at position 395 is required for Na(+)/I(-) symporter activity PMID: 12145342
14. sodium/iodide symporter gene is repressed by TGFbeta, which is regulated by interacting Pax8 and Smad3 PMID: 14623893
15. The high degree of homology in the 5'-flanking region between mouse and rat NIS suggests that mNIS and rNIS share similar mechanisms for transcriptional regulation in the thyroid. PMID: 15009910
16. Data show that tumor cells expressing the thyroidal sodium iodide symporter (NIS) retain iodide longer than thyroid cells due to a combination of slow efflux and reuptake. PMID: 15522214
17. water transport across the membrane can be explained by cotransport of water in the membrane proteins and that intracellular unstirred layers effects are minute PMID: 16322051
18. A significant proportion of human cholangiocarcinomas expresses membrane sodium iodide symporter, which may permit radioiodine therapy. Our data also suggest that (131)I acts on a crucial target for liver cancer development. PMID: 17408651
19. MEK inhibition restores NIS protein levels and NIS-mediated radioiodide uptake activity in RET/PTC oncogene-transformed thyroid cells. PMID: 17639055
20. that NIS protein levels and functional activity could be modulated by phosphorylation through distinct mechanisms. PMID: 17913707
21. Gene transfer permits sequential real-time detection and quantification of reporter gene expression in the transplanted heart with micro-SPECT/CT imaging. PMID: 18165779
22. The Na+/I- symporter mediates active iodide uptake in the intestine. PMID: 19052257

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KEGG: rno:114613

STRING: 10116.ENSRNOP00000025577

UniGene: Rn.10505