Recombinant Rat Tyrosine-protein phosphatase non-receptor type 6(Ptpn6)

Code CSB-YP019043RA
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Source Yeast
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Code CSB-EP019043RA
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Source E.coli
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Code CSB-EP019043RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP019043RA
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Source Baculovirus
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Code CSB-MP019043RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Ptpn6
Uniprot No. P81718
Alternative Names Ptpn6; Ptph6; Tyrosine-protein phosphatase non-receptor type 6; EC 3.1.3.48; Protein-tyrosine phosphatase SHP-1
Species Rattus norvegicus (Rat)
Expression Region 1-613
Target Protein Sequence MLSRGWFHRD LSGPDAETLL KGRGVPGSFL ARPSRKNQGD FSLSVRVDDQ VTHIRIQNSG DFYDLYGGEK FATSTELVEY YTQQQGILQD RDGTIIHLKY PLNCSDPTSE RWYHGHMSGG QAESLLQAKG EPWTFLVRES LSQPGDFVLS VLNDQPKAAP GSPLRVTHIK VMCEGGRYTV GGSETFDSLT DLVEHFKKTG IEEASGAFVY LRQPYYATRV NAADIENRVL ELNKKQESED TAKAGFWEEF ESLQKQEAKN LHQRLEGQRP ENKSKNRYKN ILPFDHSRVI LQGRDSNIPG SDYINANYVK NQLLGPDENS KTYIASQGCL DATVNDFWQM AWQENTRVIV MTTREVEKGR NKCVPYWPEV GTQRVYGLYS VTNCKEHDTA EYKLRTLQIS PLDNGDLVRE IWHYQYLSWP DHGVPSEPGG VLSFLDQINQ RQESLPHAGP IIVHCSAGIG RTGTIIVIDM LMESVSTKGL DCDIDIQKTI QMVRAQRSGM VQTEAQYKFI YVAIAQFIET TKKKLEIIQS QRGQESEYGN ITYPPALRSA HAKASRTSSK HKEEVYENVH SKNKKEEKVK KQRSADKEKN KGSLKRNISL TPCRGLRWAD RDL
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Gene References into Functions
  1. Shp-1 increased in DRGs of rats with CFA-induced inflammatory pain, which was involved in protecting against excessive thermal hyperalgesia. PMID: 25790452
  2. Andrographolide activates the PP2A-p38MAPK-p53-Bax cascade. PMID: 25007834
  3. SHP-1 as an off-switch of PDGFR signaling appears to emerge as a valuable molecular target to trigger as to prevent hepatic stellate cells (HSC) proliferation and the fibrogenic effects of HSC activation. PMID: 24140598
  4. Postnatal day-15 hindbrain contains a complex of proteins recruited by angiotensin (Ang)-II SHP-1 protein tyrosine activation, which participates in an active signal transduction mechanism. PMID: 22120166
  5. The activity of SHP-1 was decreased after high partial pressure of oxygen treatment no matter what the duration was, while the activity of CD45 was decreased only after high partial pressure of oxygen that led to inhibition of lymphocyte function. PMID: 21166153
  6. Adaptor protein 3BP2 directly interacts with Tyr564-phosphorylated form of SHP-1 and positively regulates the function of SHP-1 in FcepsilonRI-mediated signaling in mast cells. PMID: 22077594
  7. Nicotine-induced tyrosine phosphorylation of JAK2 and neuroprotection against Abeta (1-42) in PC12 cells are blocked by Ang II via AT2 receptor-induced activation of SHP-1 PMID: 14657181
  8. Src homology protein tyrosine phosphatase-1 might play a critical role in the transcriptional regulation of MCP-1 expression PMID: 14684844
  9. SHP-1 may play a role in limiting CNS inflammation following injury such as deafferenting the auditory brainstem. PMID: 15341919
  10. SHP-1 has a role in myocardial infarction in rats PMID: 16223786
  11. SHP-1 phosphatase activation, by Angiotensin II (Ang II) AT(2) receptors Involvement of c-Src tyrosine kinase PMID: 18680145

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Subcellular Location Cytoplasm, Nucleus
Protein Families Protein-tyrosine phosphatase family, Non-receptor class 2 subfamily
Database Links

KEGG: rno:116689

STRING: 10116.ENSRNOP00000059867

UniGene: Rn.18985

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