Recombinant Rat Voltage-dependent L-type calcium channel subunit alpha-1C(Cacna1c) ,partial

Code CSB-YP004399RA
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Source Yeast
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Code CSB-EP004399RA
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Source E.coli
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Code CSB-EP004399RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP004399RA
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Source Baculovirus
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Code CSB-MP004399RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Cacna1c
Uniprot No. P22002
Alternative Names Cacna1c; Cach2; Cacn2; Cacnl1a1; Cchl1a1Voltage-dependent L-type calcium channel subunit alpha-1C; Calcium channel; L type; alpha-1 polypeptide; isoform 1; cardiac muscle; Rat brain class C; RBC; Voltage-gated calcium channel subunit alpha Cav1.2
Species Rattus norvegicus (Rat)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
Gene References into Functions
  1. Cacna1c plays a prominent role in regulating socio-affective communication in rats. PMID: 29739816
  2. Cav 1.2 and Cav 2.2 expression increased in acute necrotizing pancreatitis. The [Ca2+]i level, which is mediated by Cav 1.2 and Cav 2.2 expression, is directly regulated by ghrelin in pancreatic acinar cells, and serum ghrelin levels may be involved in the severity of acute pancreatitis. PMID: 29436604
  3. NFAT5-mediated expression of CACNA1C is evolutionarily conserved. NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation. PMID: 27368804
  4. Inhibition of CaV1.2 upregulates AT1R signaling in response to angiotensin II. PMID: 28514967
  5. Data indicate that in rats, central L-type calcium Cav1.2 channels, rather than Cav1.3, mediate alcohol-seeking behavior. PMID: 27905406
  6. NMDA reduced both currents in a concentration-dependent manner, whereas there was no significant impact on the currents when perfused with MK-801. MDD rats exhibited significantly more fibrosis areas in heart tissue and reduced expression of Kv4.2, Kv4.3, and Cav1.2. PMID: 28566490
  7. Rab25 is expressed in arterial myocytes where it promotes surface expression of CaV1.2 channels to control pressure- and depolarization-induced vasoconstriction. PMID: 27076616
  8. the effects of thiamine deficiency on cerebellum granule neurons, an increase in Ca(2+) current density and CaV1.2 expression, is reported. PMID: 27140189
  9. Our findings indicate that Ca(v)1.2 and 5-HT alterations could cause abnormal cardiac function, and the proteins investigated here may be useful for investigating the mechanisms underlying positional asphyxia. PMID: 26471941
  10. the consensus motifs of S-nitrosylation were much more abundant in Cav2.2 than in Cav1.2 and Cav2.1. PMID: 26507659
  11. In hydrogen peroxide-treated cardiomyocytes, lysophosphatidic acid decreased Ca(v)1.2 mRNA and protein expression levels at 4 and 8h, respectively. PMID: 25841350
  12. Expression of the CaV1.3 alpha1 subunit increased in parallel with AWS development, suggesting that altered L-type CaV1.3 channel expression is an important feature of AWS pathogenesis. PMID: 25556199
  13. Cav1.2 might be regulated by HIF-1a as one of its downstream target genes and involved in regulation of PC12 cells death under hypoxia. PMID: 25648081
  14. our data indicate that calcium regulation of Cav1.2 channels is more complex than previously thought, and involves more than one region within the channel's N-terminal domain. PMID: 24352630
  15. Exposing neonatal rat ventricular myocytes to hypo-osmotic medium resulted in an increase in alpha1C protein levels, a response that was prevented by PC-1 knockdown. PMID: 25888683
  16. LTCCalpha 1C is a vascular smooth muscle cell contractile phenotype marker gene. PMID: 25614710
  17. In conclusion, Ca(2) influx through Ca(V)1.2 or to Ca(V)1.3 channel subtypes contributes to maintenance of the resting membrane potentials of NGF-differentiated PC12 cells. PMID: 25675390
  18. These results suggest that Ser(1574) (C1 site) of Cav1.2 may be a potential site for the channel modulation mediated by protein kinase A. PMID: 25209265
  19. The II-III loop of Cav1.2 as a key molecular determinant that couples the channel to Ca(2+)-induced Ca(2+) release and activation of SK channels in pancreatic beta-cells. PMID: 24506535
  20. Distal C terminus of CaV1.2 channels plays a crucial role in the neural differentiation of dental pulp stem cells. PMID: 24278424
  21. Western blot analysis of the total expression levels revealed significant reductions in both Cav 1.2 and Cav 1.3 subunits from all three major hippocampal regions of aged rats. PMID: 24033980
  22. The purpose of the present study was to analyze the relative expression of VDR and LVSCCA1C in the hippocampus of rats exposed to single prolonged stress (SPS). PMID: 24535566
  23. Structural changes in CaM that arise directly from site directed mutagenesis of calcium binding domains alter activation gating of Cav1.2 channels. PMID: 24775099
  24. With the reintroduction of cav1.2 expression, neurotransmitter release is restored in the MKP3-expressing PC12 cells. PMID: 23337371
  25. Submucosal neurons, identified by a neuronal marker (microtubule-associated protein 2), are immunoreactive for Ca(v)1.2, Ca(v)1.3 and Ca(v)2.2, expression being confirmed by reverse transcription plus the polymerase chain reaction PMID: 23807706
  26. The expression levels of dihydropyridine alpha1c receptor and RyR3 receptor subunits in the rat diaphragm are unaffected by sepsis. PMID: 23943510
  27. role of eIF3e in trafficking of L-type CaV1.2 channels upon beta-cell stimulation PMID: 23737983
  28. expression of Cav1.2Delta73 alpha1-subunits in A7r5 cells inhibits endogenous Cav1.2 currents; the fact that this variant arises naturally by alternative splicing raises the possibility that it may represent a physiological mechanism to modulate Cav1.2 functional activity PMID: 23926129
  29. Cav1.2 and Cav2.3 in colonic primary sensory neurons play an important role in visceral inflammatory hyperalgesia, which maybe the potential therapeutic targets. PMID: 23537331
  30. Memory reconsolidation and its maintenance depend on L-voltage-dependent calcium channels and CaMKII functions regulating protein turnover in the hippocampus. PMID: 23576750
  31. these data suggest that Kv3.4 and Cav1.2 may act together to control Ca(2) -dependent electrical activity of pioneer axons and play important roles during axon pathfinding PMID: 22473424
  32. L- and T-type Ca(2+) channels are expressed in cerebral arterial smooth muscle and both conductances contribute to myogenic tone. PMID: 23103495
  33. Repeated cold exposure can establish cold-induced hypertension, and the level of vascular smooth muscle cell LTCCalpha1C expression increases. PMID: 21619826
  34. The Brugada syndrome mutation A39V when introduced into rat brain Cav1.2 does not trigger the loss-of-trafficking phenotype seen in a previous study on the human heart isoform of the channel PMID: 22385640
  35. Osthole speeded up the inactivation kinetics of I(Ca1.2). PMID: 22329900
  36. Data demonstrate that AKAP79/150 colocalizes with TRPV1 and Ca(V) 1.2 in the soma and axon initial segment in a subset of small DRG sensory neurons. PMID: 21674494
  37. Gal-1 regulates I(Ca,L) by decreasing the surface expression of Ca(V)1.2 channels in a splice variant selective manner. This may modulate vasoconstriction. Gal-1 binds the I-II loop only in the absence of alternatively spliced exon 9*. PMID: 21998324
  38. Oxidative stress during inflammation impairs the integrity of the promoter of Cacna1c; impairment persists partially after inflammation has subsided. Reduced transcription of Cacna1c contributes to smooth muscle dysfunction in the absence of inflammation. PMID: 21745450
  39. The authors show here that a single microRNA, miR-103, simultaneously regulates the expression of the three subunits forming Cav1.2-comprising L-type calcium channel in a novel integrative regulation. PMID: 21804529
  40. The aim of this study is to investigate LVSCC-A1C, LVSCC-A1D expression levels and NGF release in VDR-silenced primary cortical neurons. PMID: 21408608
  41. Interactions between alpha5beta1-integrin and fibronectin can modulate L-type calcium channel entry and consequently alter the physiological function of multiple types of excitable cells. PMID: 21178109
  42. A couplon contains 74 RyR tetramers and 10 copies of the alpha-subunit of Cav1.2. PMID: 21156134
  43. angiotensin II stimulates endothelial NAD(P)H oxidase-produced H(2)O(2,) which may additionally act through vascular smooth muscle NAD(P)H oxidase, to upregulate vascular Ca(V)1.2 protein PMID: 20639649
  44. The single nucleotide polymorphisms FKBP5:rs1360780, BDNF:rs6265 (Val66Met), P2RX7:2230912 (Gln460Arg) and CACNA1C:rs1006737 were genotyped in DNA from 457 depression cases (major depression, dysthymia, and mixed anxiety depression. PMID: 20226536
  45. study found that STIM1 suppresses depolarization-induced opening of the voltage-gated Ca(2+) channel Ca(V)1.2; STIM1 binds to the C terminus of Ca(V)1.2, inhibits gating and causes long-term internalization of the channel from the membrane PMID: 20929812
  46. STIM1 activation by store depletion or mutational modification suppresses Ca(V)1.2 channels while activating store-operated Orai channels; STIM1 interacts with and reciprocally controls 2 major calcium channels hitherto thought to operate independently PMID: 20929813
  47. Mitochondria sense IP(3)R-mediated sarcoplasmic reticulum Ca(2+) release to control NF-kappaB-dependent Ca(V)1.2 channel expression in arterial myocytes, thereby modulating arterial contractility. PMID: 20616314
  48. The traditional modeling of irritable bowel syndrome in rats alters the expression of Cav1.2 and Cav1.3. PMID: 20137275
  49. Coupled gating of Cav1.2 channels may represent a novel mechanism for the regulation of Ca(2+) influx and excitability in neurons, cardiac, and arterial smooth muscle under physiological and pathological conditions. PMID: 20110531
  50. The location of L-type Ca(v)1.2 and Ca(v)1.3 channels in distal dendrites and spines on hippocampal neurons places them at appropriate sites where they could initiate synapse to nucleus signalling. PMID: 19665524

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Subcellular Location Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma; Multi-pass membrane protein. Perikaryon. Cell junction, synapse, postsynaptic density membrane. Cell projection, dendrite. Cell membrane, sarcolemma, T-tubule.
Protein Families Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1C subfamily
Tissue Specificity Detected in hippocampus and brain cortex, on neuronal cell bodies and dendrites, and in post-synaptic density in brain (at protein level). Isoforms 4 and 5 are expressed throughout the central nervous system, with highest levels in the olfactory bulb and
Database Links

KEGG: rno:24239

STRING: 10116.ENSRNOP00000048790

UniGene: Rn.9827

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