Recombinant Saccharomyces cerevisiae Exodeoxyribonuclease 1 (EXO1), partial

1. Exo1-dependent and independent mismatch repair has been described. (Review) PMID: 25956862
2. When RNR is induced in the absence of Exo1 and RNR negative regulators, cell viability of rad53 mutants treated with HU is increased and the ability of replication forks to restart after replicative stress is restored. PMID: 25601385
3. Exo1 function in the DNA-damage response and the regulation of these functions by phosphorylation PMID: 25457771
4. We show that the loss of Exo1p reduces the rate of UV-induced, but not spontaneous, recombination events and that the lengths of crossover-associated conversion events are reduced in the exo1 strain. PMID: 24835424
5. Occurrence of duplication of the targeted chromosome was strikingly increased in the exo1Delta sgs1Delta double mutant but not in the respective single mutants. PMID: 25089886
6. Models for the functional interactions of mitotic cyclin Clb2, Sgs1 and Exo1 with replication fork stabilization are proposed. PMID: 25771727
7. Characterization of the sensitivity of single, double and triple mutants for Exo1, Mre11 and Pso2 nucleases in Saccharomyces cerevisiae to various DNA damaging agents reveals complex interactions that depend on the type of DNA damage. PMID: 18295552
8. Deletion of Exo1 reduces efficiency of mismatch repair of errors made by Pol1 even more than for errors made by Pol3. PMID: 23245696
9. A prototypical Franconi anemia-related interstrand crosslink repair pathway operates in budding yeast, which acts redundantly with the pathway controlled by Pso2, and is required for the targeting of Exo1 to chromatin to execute DNA repair. PMID: 22912599
10. Data provide a model that indicates how in Rad53 or MRX mutants, an inappropriately active Exo1 may facilitate faulty template switching between nearby inverted repeats to form dicentric chromosomes. PMID: 21098663
11. Mre11 and Exo1 are the major nucleases involved in creating resection tracts of widely varying lengths typical of meiotic recombination. PMID: 21146476
12. Exo1 also plays a nuclease-independent role in crossover promotion. PMID: 21044871
13. Exo1 processes nucleotide excision repair (NER) intermediates when repair synthesis is impeded, converting NER intermediates to long ssDNA gaps and promoting checkpoint activation. PMID: 20932474
14. In the absence of end protection by Ku, the requirement for the MRX complex is bypassed and 5'-3' resection of double-strand break ends is executed by Exo1. PMID: 20729809
15. Exo1 exonuclease is an initiator of the recombination process that allows cells to escape senescence and become immortal in the absence of telomerase. PMID: 15126386
16. Exo1 can make either positive or negative contributions to telomere function and cell viability, depending on whether telomerase or recombination is utilized to maintain telomere function. PMID: 15126387
17. Exo1 is critical for generating ssDNA in subtelomeric X repeats and internal single-copy sequences of Saccharomyces cerevisiae cdc13-1 mutants. PMID: 15454530
18. Exo1 exonuclease is recruited to stalled forks and, in rad53 mutants, counteracts reversed fork accumulation PMID: 15629726
19. Exo1p plays both structural and catalytic roles during DNA mismatch repair. PMID: 17602897
20. SNPs associated with prognosis of lung cancer was mapped to EXO1. PMID: 17855454
21. Rad53-dependent Exo1 phosphorylation is involved in a negative feedback loop to limit ssDNA accumulation and DNA damage checkpoint activation PMID: 18756267
22. Deletion of SGS1 or DNA2 reduces resection and DSB repair by single-strand annealing between distant repeats while the remaining long-range resection activity depends on the exonuclease Exo1. PMID: 18805091
23. yeast Exo1 nuclease and Sgs1 helicase function in alternative pathways for double strand break processing PMID: 18806779
24. The site S2 in Mlh1 mediates Exo1 recruitment in order to optimize mismatch repair-dependent mutation avoidance. PMID: 19015241
25. Data further show that Dna2 might support Sgs1 activity, as it acts redundantly with Exo1, but not with Sgs1 in telomere processing. PMID: 19595717

Show More

Hide All

KEGG: sce:YOR033C

STRING: 4932.YOR033C