Recombinant Sheep Growth/differentiation factor 8 (MSTN)

1. Data show that disruption of the myostatin (MSTN) gene resulted in the desired muscle hypertrophy. PMID: 27562433
2. The effect of these SNPs on growth and carcass traits was investigated in 357 New Zealand Romney lambs in addition to 2 previously identified SNPs, c.-2379C was associated with increased birthweight, tailing weight and weaning weight. PMID: 26081604
3. We determined the efficiency of the CRISPR/Cas9 system to edit MSTN in sheep and generate knock-out (KO) animals with the aim to promote muscle development and body growth PMID: 26305800
4. Data show that Yes-associated protein 1 (YAP1) expression was significantly or and positively correlated with (MSTN) and myogenin (MyoG) at 2 days old, 2 and 6 months old. PMID: 25966090
5. we demonstrate zygote injection of TALEN mRNA can also produce gene-edited cattle and sheep. In both species we have targeted the myostatin (MSTN) gene. PMID: 25204701
6. The mRNA expression levels of MSTN, IGF-1 and IGF-2 were significantly different in the same skeletal muscle under different dietary intake. PMID: 25078581
7. Silencing of myostatin using shRNA may provide a feasible approach to improve meat productivity in farm animals PMID: 24052475
8. myostatin splice variant represents a unique example of intra-genic regulation in which a splice variant directly antagonizes the biological activity of the canonical gene product PMID: 24312578
9. CAST and GDF-8 genes are associated with lower values of lamb meat tenderness and is related to the stage of muscular growth and development. PMID: 24338411
10. The myostatin g+6723G>A mutation did not affect sensory meat quality traits of grilled steaks for the longissimus lumborum muscle, but resulted in a significant improvement in eating quality for the semimembranosus muscle. PMID: 23680643
11. shRNAs targeting MSTN were expressed in muscles of transgenic sheep. MSTN expression was inhibited in muscle tissues of transgenics compared with controls. Moreover, transgenic sheep showed a tendency to faster increase in body weight than control sheep. PMID: 23526994
12. Polymorphism in the ovine myostatin gene is associated with birth weight, but not with weight gain in Iranian Makoei sheep. PMID: 23096682
13. these results demonstrate that MSTN plays critical role in myoblast differentiation in sheep, analogous to that in mice. PMID: 22580276
14. Studied myostatin silencing in sheep fetal fibroblasts using Sleeping Beauty transposon. PMID: 21698446
15. Two and four polymorphic loci of MSTN gene were revealed in the 5'UTR and intron I PMID: 21323579
16. The recent progress in mapping quantitative trait nucleotides (QTNs) are reviewed, including the ABCG2 gene mutation that underlies a QTL for fat and protein content and the ovine MSTN gene mutation that causes muscular hypertrophy in Texel sheep. PMID: 20720303
17. 3'UTR g+6223G-->A mutation operates by promoting RNA-Induced Silencing Complex-dependent down-regulation of myostatin (MSTN) in skeletal muscle of Texel sheep. PMID: 20679369
18. Two myostatin mutations were found to reduce fatness and increase muscle mass, although the effect of the frameshift mutation (c.960delG) was more important as compared to the 3'-UTR mutation (c.2360G>A). PMID: 20113462
19. These results suggest that variation in ovine MSTN is associated with meat production, but not birth weight or growth rate in New Zealand Romney sheep. PMID: 19799595
20. A QTL affecting muscle and fat traits exists within the New Zealand Texel population and it maps to the region of GDF8 on OAR2. PMID: 16100053
21. The results showed that E-box (E) 3, E4, E5 and E7, particularly E3, E5 and E7, had important effects on the activity of the 1.2 kb sheep myostatin promoter. PMID: 17669271
22. The detection of three alleles and the identification of sequence variation in the ovine GDF8 coding region is reported. PMID: 17935943
23. Two SNPs in GDF8 are associated with greater muscle depth in Charollais sheep. PMID: 18462481
24. distribution of 3 genotypes in 11 sheep breeds was significantly different PMID: 19073574
25. The results provide evidence that the g+6723G-A transition in GDF8 is the underlying SNP for the QTL affecting muscling previously identified in the New Zealand Texel sheep population. PMID: 19251921

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KEGG: oas:443449

UniGene: Oar.563