Recombinant Xenopus laevis Retinoic acid receptor RXR-alpha(rxra)

Code CSB-YP020612XBE
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Source Yeast
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Code CSB-EP020612XBE
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Source E.coli
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Code CSB-EP020612XBE-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP020612XBE
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Source Baculovirus
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Code CSB-MP020612XBE
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names rxra
Uniprot No. P51128
Alternative Names rxra; nr2b1Retinoic acid receptor RXR-alpha; Nuclear receptor subfamily 2 group B member 1; Retinoid X receptor alpha
Species Xenopus laevis (African clawed frog)
Expression Region 1-488
Target Protein Sequence MSSAAMDTKH FLPLGGRTCA DTLRCTTSWT AGYDFSSQVN SSSLSSSGLR GSMTAPLLHP SLGNSGLNNS LGSPTQLPSP LSSPINGMGP PFSVISPPLG PSMAIPSTPG LGYGTGSPQI HSPMNSVSST EDIKPPPGIN GILKVPMHPS GAMASFTKHI CAICGDRSSG KHYGVYSCEG CKGFFKRTVR KDLTYTCRDS KDCMIDKRQR NRCQYCRYQK CLAMGMKREA VQEERQRGKE RNENEVESSN SANEDMPVEK ILEAEHAVEP KTETYTEANM GLAPNSPSDP VTNICQAADK QLFTLVEWAK RIPHFSELPL DDQVILLRAG WNELLIASFS HRSIAVKDGI LLATGLHVHR NSAHSAGVGA IFDRVLTELV SKMRDMQMDK TELGCLRAIV LFNPDSKGLS NPLEVEALRE KVYASLEAYC KQKYPEQPGR FAKLLLRLPA LRSIGLKCLE HLFFFKLIGD TPIDTFLMEM LEAPHQMT
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription. The high affinity ligand for rxrs is 9-cis retinoic acid. In the absence of ligand, the rar/rxr heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation.
Subcellular Location Nucleus.
Protein Families Nuclear hormone receptor family, NR2 subfamily
Database Links

UniGene: Xl.877

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