AGPS Recombinant Monoclonal Antibody

Datasheet

Code	CSB-RA196051A0HU
Size	US$210
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Image	Flow cytometric analysis of Alkylglycerone phosphate synthase expression in HeLa cells using Alkylglycerone phosphate synthase antibody. Green, isotype control; red, Alkylglycerone phosphate synthase. Immunocytochemical staining of Hela cells with Alkylglycerone phosphate synthase antibody. Nuclei were stained blue with DAPI; Alkylglycerone phosphate synthase was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 μm. Western blotting analysis using alkylglycerone phosphate synthase antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with alkylglycerone phosphate synthase antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
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Target Background

Product Details

Uniprot No.

O00116

Target Names

AGPS

Alternative Names

AGPS; Alkylglycerone Phosphate Synthase; ALDHPSY; ADHAPS; ADAP-S; ADAS; ADPS; Alkyldihydroxyacetonephosphate Synthase, Peroxisomal; Aging-Associated Gene 5 Protein; Alkyl-DHAP Synthase; EC 2.5.1.26; Alkylglycerone-Phosphate Synthase; Aging-Associated Protein 5; RCDP3

Species Reactivity

Human, Rat

Immunogen

Recombinant Human AGPS protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

Rabbit IgG

Clone No.

22B9

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Form

Liquid

Tested Applications

ELISA, WB, FC, ICC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
FC	1:200-1:2000
ICC	1:100-1:1000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Flow Cytometry (FC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis.

Gene References into Functions

we optimized the BITC construction targeting alkylglycerone phosphate synthase (AGPS) by computer-aided design, and the derivants also showed anti-tumor potential in vitro. PMID: 25542233
AGPS overexpression could be a causation of chemotherapy agent resistance of cancer cells. AGPS silencing could lead to drug uptake and cell cycle arrest and apoptotic cell death. PMID: 24815474
Results demonstrated that AGPS negatively regulated the invasion potential of glioma and hepatic carcinoma cells by modulating the expression of relevant genes and activity of the MAPK pathway. PMID: 24841318
AGPS, in addition to maintaining ether lipids, also controls cellular utilization of fatty acids, favoring the generation of signaling lipids necessary for promoting the aggressive features of cancer. PMID: 23980144
Novel mutations in AGPS (alkylglycerone-phosphate synthase) cause rhizomelic chondrodysplasia punctata (RCDP) type 3. PMID: 21990100
Defect of ADAPS expression was also assessed by immunoblot PMID: 18571506

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Involvement in disease

Rhizomelic chondrodysplasia punctata 3 (RCDP3)

Subcellular Location

Peroxisome membrane. Peroxisome.

Protein Families

FAD-binding oxidoreductase/transferase type 4 family

Database Links

HGNC: 327

OMIM: 600121

KEGG: hsa:8540

STRING: 9606.ENSP00000264167

UniGene: Hs.516543

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Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Virus Infection Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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