Code | CSB-RA266893A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:5000 |
The recombinant ALAS1 antibody is a monoclonal antibody molecule expressed by using recombinant DNA and protein engineering technology to clone the genes encoding the ALAS1 antibody into a plasma vector and then by transfecting the vector clone into the appropriate recipient mammalian cells for production. It was purified using affinity-chromatography. And it shows reactivity with ALAS1 protein from Human. This recombinant ALAS1 antibody can be used in the ELISA, WB.
ALAS1 is a mitochondrial enzyme that catalyzes the condensation of glycine and succinyl-CoA generating 5-aminolevulinic acid. As a rate-limiting enzyme of the heme biosynthetic pathway, ALAS1 provides a basal level of heme in nonerythropoietic cells for cytochromes and other hemoproteins. ALAS1 is tightly controlled to adjust to hepatocytes' metabolic demands. ALAS1 deficiency causes embryonic mortality in mice, showing that it is required for early embryogenesis.
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