Code | CSB-RA252650A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:5000 |
The BCHE monoclonal antibody was generated by immunizing animals with a synthesized peptide derived from human BCHE, followed by the isolation of B cells and fusion with myeloma cells to generate hybridomas. The variable light and variable heavy domains of BCHE antibody-producing hybridomas were sequenced, and the resulting gene was cloned into a vector. After transfecting the recombinant vector into cells for cultivation, the BCHE recombinant monoclonal antibody was isolated and purified using affinity chromatography from the cell culture supernatant. This purified antibody has been tested for the detection of human BCHE protein in both ELISA and WB applications.
The BCHE protein, also known as pseudocholinesterase, is an enzyme that plays a role in the metabolism of certain drugs and chemicals in the body, including choline esters and succinylcholine. BCHE is primarily produced in the liver but is also found in other tissues, including the brain, and is involved in the breakdown of acetylcholine, a neurotransmitter that is important for the proper functioning of the nervous system. BCHE is also involved in various physiological processes, including inflammation, apoptosis, and the regulation of nerve growth factors. Mutations in the BCHE gene have been associated with various diseases, including drug toxicity, neuromuscular disorders, and Alzheimer's disease.
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