Code | CSB-RA166177A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:2000 |
The production of the CD58 recombinant monoclonal antibody involves genetic engineering procedures that entail the cloning and expression of the CD58 monoclonal antibody-encoding gene. The synthesized peptide, derived from the human CD58 protein, serves as the immunogen for generating the CD58 monoclonal antibody. To ensure high purity, the CD58 recombinant monoclonal antibody is purified through affinity chromatography. The specificity of the CD58 recombinant monoclonal antibody allows it to recognize and bind to the CD58 protein with high precision. Rigorous validation and testing, including ELISA and WB applications, have confirmed the quality and specificity of the CD58 recombinant monoclonal antibody for use in human samples.
CD58, also known as LFA-3, is a glycoprotein that is expressed on the surface of many types of cells, including B cells, T cells, and NK cells. Its main function is to bind to CD2, which is another glycoprotein found on the surface of T cells and NK cells, and this interaction facilitates the activation of these cells. CD58 also plays a crucial role in the immune response by regulating adhesion and co-stimulation between cells. It helps in the formation of the immunological synapse, which is a specialized interface between T cells and antigen-presenting cells, that allows for effective communication between these cells. It is also involved in the pathogenesis of certain diseases such as multiple sclerosis and rheumatoid arthritis, as it plays a role in the activation and migration of immune cells to inflamed tissues.
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