CLEC3B Recombinant Monoclonal Antibody

CLEC3B, also known as tetranectin, is a C-type lectin that plays important roles in tissue remodeling, fibrinolysis, and mineralization processes. This trimeric protein binds specifically to the kringle 4 domain of plasminogen, positioning it as a key regulator of plasminogen activation and extracellular matrix dynamics. Researchers investigating cancer progression, bone development, cardiovascular disease, and wound healing frequently study CLEC3B due to its altered expression patterns in various pathological conditions and its potential as a biomarker.

This recombinant monoclonal antibody, clone 3H11, offers the reproducibility and consistency that demanding research protocols require. Developed using recombinant technology with a defined sequence, this rabbit IgG eliminates the lot-to-lot variability that can compromise longitudinal studies and multi-site collaborations. The antibody was raised against a synthetic peptide derived from human CLEC3B, ensuring precise epitope targeting.

Validation studies confirm reliable performance in flow cytometry applications, with recommended dilutions ranging from 1:50 to 1:200. Testing in MCF-7 cells demonstrated clear positive signal separation from isotype control, with fixed and permeabilized cells showing robust intracellular detection of CLEC3B. The antibody has also been validated for ELISA, providing flexibility for researchers who need to quantify CLEC3B levels across different experimental platforms.

Supplied in a stabilized liquid format with glycerol for convenient long-term storage, this affinity-purified antibody is ready for immediate use in your human sample studies. Whether you are exploring tetranectin's role in tumor microenvironment remodeling or investigating its function in mineralization pathways, this antibody delivers the specificity and consistency your research demands.