Casp7 Recombinant Monoclonal Antibody

1. Caspase 7 has a nonapoptic function that participates in normal spermatogenesis, but also displays apoptotic function in spermatogenic dysfunction. PMID: 26643564
2. Our study shows for the first time activated caspase-7 in hair follicles and mast cells and indicates its non-apoptotic roles in the skin. PMID: 26253163
3. Optic nerve crush activated caspase-7 in retinal ganglion cells followed by cell death. Knockout of caspase-7 partially and significantly protected against ON injury-induced RGC loss. PMID: 26306916
4. genetic loss of caspase-7 promotes solar-simulated light-induced skin carcinogenesis by blocking caspase-7-mediated cleavage of keratin-17. PMID: 26271098
5. In vitro, with application of specific inhibitors and siRNA, AND-induced apoptosis was proven through ROS-ERK-P53-caspase 7-PARP signaling pathway PMID: 25162007
6. The scotopic electroretinography demonstrated that the ablation of the CASP7 in T17M RHO retina leads to significant preservation of the function of photoreceptors compared to controls. PMID: 24664731
7. Data suggest that caspase-7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices. PMID: 23713787
8. The results indicate a non-essential apoptotic role of caspase-7 in the PEK apoptosis but suggest also possible non-apoptotic functions for caspase-7 in tooth development. PMID: 22858065
9. host activation of caspase-7 in response to pore formation represents an adaptive mechanism by which host cells can protect membrane integrity during Listeria monocytogenes infection PMID: 22807671
10. An apoptosis-independent regulatory role for caspase 7-mediated PARP1 cleavage in proinflammatory gene expression is discussed. PMID: 22464733
11. Our findings demonstrate for the first time a strong correlation between caspase-7 activity, normal brain development, and apoptotic DNA fragmentation in Casp3-/- mice. PMID: 15525783
12. Our results show that in contrast to dermal fibroblasts and cortical neurons, sympathetic neurons express no detectable levels of caspase-7. PMID: 16932756
13. proteolytic processing of ataxin-7 by caspase-7 may contribute to SCA7 disease pathogenesis PMID: 17646170
14. Caspase-7 was activated in the splenocytes of LPS-injected mice. CASP-7-deficient mice resist LPS-induced lymphocyte apoptosis & are protected from LPS-induced lethality independently of the excessive production of serum cytokines. PMID: 19168786
15. results reveal a new mechanism for caspase-7 activation downstream of the Nlrc4 inflammasome and present a novel biological role for caspase-7 in host defense against Legionella pneumophila PMID: 19343209
16. In mid-gestational wounds, activation of apoptotic pathways may be mediated through effector caspase 7 signals with inactivation of PARP. PMID: 19555972

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KEGG: mmu:12369

STRING: 10090.ENSMUSP00000026062

UniGene: Mm.35687