Code | CSB-RA287686A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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FC | 1:50-1:200 |
The synthesis of the DARC recombinant monoclonal antibody involves a stepwise procedure, commencing with in vitro cloning. This initial step entails the integration of genes encoding both the heavy and light chains of the DARC antibody into expression vectors. Subsequently, the constructed expression vectors are introduced into host cells, facilitating the recombinant antibody's expression within a cell culture environment. After this expression, the DARC recombinant monoclonal antibody is isolated from the supernatant of transfected host cell lines through the utilization of affinity chromatography for purification. Noteworthy is its specific binding capacity to the human DARC protein, as well as its remarkable versatility for ELISA and FC applications.
DARC is a cell surface receptor that binds to specific chemokines, regulating leukocyte trafficking and immune responses. Its ability to sequester chemokines in the bloodstream has implications for inflammation and immunity. Additionally, DARC is known for its involvement in blood group determination and its association with resistance to certain types of malaria.
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