Code | CSB-RA548809A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
The recombinant FLNA antibody was prepared by obtaining the antibody genes, cloning the genes into a plasma vector to construct vector clone, transfecting the vector clone into a mammalian cell line for transient expression, and purifying the antibody by affinity-chromatography. This recombinant FLNA antibody has been verified to detect the FLNA protein from Human in the ELISA, IHC.
FLNA is an important actin cross-linking protein that attaches actin filaments in smooth muscle cells (SMCs) to transmembrane integrin molecules in focal adhesions of the cell membrane. It thus plays a central role in maintaining cell morphology, cell signaling, cell migration, and adhesion. FLNA mutations have been linked to a wide range of disorders, including bilateral contiguous PVH in females and periventricular nodular heterotopia. Alterations in FLNA expression are responsible for the development and progression of various cancers.
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