Code | CSB-EP008724HU |
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Size | US$306 |
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Amino acids 2-274 constitute the expression domain of recombinant Human FLNA. This FLNA protein is theoretically predicted to have a molecular weight of 38.0 kDa. This protein is generated in a e.coli-based system. The FLNA gene fragment has been modified by fusing the N-terminal 10xHis tag and C-terminal Myc tag, providing convenience in detecting and purifying the recombinant FLNA protein during the following stages.
Filamin-A (FLNA) is a large actin-binding protein that plays a crucial role in the organization and maintenance of the actin cytoskeleton. It functions as a scaffold, linking cell membrane receptors to the actin network, and contributing to cell adhesion, migration, and signaling. FLNA is involved in various cellular processes, including embryonic development, tissue morphogenesis, and response to mechanical stimuli. Mutations in FLNA are associated with a spectrum of genetic disorders known as filaminopathies, characterized by skeletal abnormalities, cardiovascular defects, and neurological impairments. Additionally, FLNA has been implicated in cancer progression, where its dysregulation influences cell motility and invasion.There are currently no reviews for this product.