Code | CSB-RA009899A0HU |
Size | US$210 |
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The recombinant GRIA2 antibody production commenced with the obtaining of genes encoding antibody against GRIA2. Antibody genes were obtained by sequencing and screening DNA reversely transcribed from RNA that was extracted from the B cells isolated from immunized animals. These genes were cloned into plasma vectors and subsequently transfected into a mammalian cell line for production. The product is the recombinant GRIA2 antibody. It underwent purification using affinity-chromatography from the cell culture medium. This recombinant GRIA2 antibody has been validated to detect the GRIA2 protein from Human in the ELISA.
GRIA2 is the encoding gene for the GluA2 subunit, which plays a central role in the modulation of AMPAR properties such as calcium permeability, single-channel conductance, and receptor trafficking at the synapse, as well as synaptic plasticity. When present in the AMPARs, the GluA2 subunit, in its classical postnatally edited form, makes the receptor ion channel impermeable to calcium and insensitive to voltage-dependent blockade by intracellular polyamines, such ad spermine. Reduced expression of the GluA2 subunit in AMPA receptors increases calcium permeability resulting in a lower seizure threshold.
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