Code | CSB-RA172768A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IF | 1:50-1:200 |
FC | 1:50-1:200 |
The production of the ITGA6 recombinant monoclonal antibody is a sophisticated procedure requiring several steps. Initially, the ITGA6 monoclonal antibody is collected and its gene sequence is analyzed. A vector that carries the ITGA6 monoclonal antibody gene is then constructed and transfected into a host cell line for culture. During ITGA6 monoclonal antibody synthesis, a synthesized peptide based on human ITGA6 is utilized as the immunogen. The ITGA6 recombinant monoclonal antibody is purified using affinity chromatography, and its specificity is then tested using ELISA, IF, and FC applications.
ITGA6 is a transmembrane protein that acts as a receptor for laminin-1, laminin-2, laminin-10, laminin-11, and several other extracellular matrix (ECM) proteins. In cells, ITGA6 is involved in cell adhesion, migration, differentiation, proliferation, and survival. The binding of ITGA6 to its ligands activates various signaling pathways, including the PI3K-Akt and MAPK pathways, which regulate several cellular processes. ITGA6 is also known to interact with other proteins, such as CD151 and integrin beta-4, to form heterodimers that modulate integrin signaling and function.
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