Code | CSB-RA787996A0HU |
Size | US$210 |
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The ITGAL recombinant monoclonal antibody is created through a series of intricate procedures. Firstly, the ITGAL monoclonal antibody is harvested, and its gene sequence is analyzed. A vector with the ITGAL monoclonal antibody gene is then constructed and introduced into a host cell line for culture. The synthesized peptide from human ITGAL is used as an immunogen for the ITGAL monoclonal antibody production. The ITGAL recombinant monoclonal antibody is then purified via affinity chromatography, and its specificity is tested through ELISA, WB, and IF applications. It only reacts with human ITGAL protein.
ITGAL protein is a cell adhesion molecule that plays a key role in immune responses. It is primarily expressed on the surface of leukocytes, including T cells, B cells, monocytes, and granulocytes, and is responsible for mediating leukocyte adhesion and migration through interactions with ligands such as ICAM-1 and ICAM-2 on the surface of endothelial cells. This process is essential for immune cell recruitment to sites of inflammation and infection. Additionally, ITGAL is involved in the formation of immunological synapses between T cells and antigen-presenting cells, which is important for the activation of T cells and the initiation of an immune response.
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