Il1rap Recombinant Monoclonal Antibody

Datasheet

Code	CSB-RA730751MA1MO
Size	US$210
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Image	The Binding Activity of Mouse Il1rap with Anti-Il1rap recombinant antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Il1rap protein (CSB-MP730751MO) at 2 μg/mL can bind Anti-Il1rap recombinant antibody. The EC₅₀ is 2.279-3.955 ng/mL. The Binding Activity of Rat Il1rap with Anti-Il1rap recombinant antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Rat Il1rap protein (CSB-MP733954RA) at 2 μg/mL can bind Anti-Il1rap recombinant antibody. The EC₅₀ is 3.180-4.082 ng/mL.
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q61730

Target Names

Il1rap

Alternative Names

Il1rap; Interleukin-1 receptor accessory protein; IL-1 receptor accessory protein; IL-1RAcP; EC 3.2.2.6; Interleukin-33 receptot beta chain

Species Reactivity

Human

Immunogen

Recombinant Mouse Il1rap protein

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

mIgG2a

Clone No.

10D6

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Recommended Dilution

Application	Recommended Dilution
ELISA	1:5000-1:50000

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD. May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells.; Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling.; Required for Src phosphorylation by IL1B. Required for IL1B-potentiated NMDA-induced calcium influx in neurons acting in cooperation with IL1R1 isoform 2 to mediate Akt kinase activation.

Gene References into Functions

These results thus reveal the decoding mechanism of splice-insert signaling codes for synaptic differentiation induced by trans-synaptic adhesion between PTPdelta and IL1RAPL1/IL-1RAcP. PMID: 25908590
We conclude that neuron-specific AcPb plays a critical role in host defenses and sleep homeostasis. PMID: 25449578
In experimental biliary atresia, miR-29a/29b1 are upregulated, and reporter assays confirmed that Igf1 and Il1RAP are down-regulated by miR-29. PMID: 22167021
The results of this study suggested that IL-1RAcP represents an interesting molecular link between immune systems and synapse formation in the brain. PMID: 22357843
IL-1RAcP is essential for physiological activities of peripheral IL-1. PMID: 11847485
Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling PMID: 11880380
determination of interaction sites in vitro mutagenesis and molecular modeling PMID: 13679373
data suggest that domain III of IL-1RAcP may be involved in the formation or stabilization of the IL-1RI/IL-1 complex by binding to epitopes on domain III of the IL-1RI created following IL-1 binding to the IL-1RI PMID: 17669273
IL-33 and ST2 form a complex with IL-1R accessory protein (IL-1RAcP), a signaling receptor subunit that is also a member of the IL-1R complex. PMID: 17675517
IL-1RAcP is used by more than one alpha-chain of the IL-1 receptor family and thus may resemble a common beta-chain of that family PMID: 18003919
these observations establish AcP as co-receptor for IL-33 signaling via ST2 and suggest a novel role for sAcP in modulating the biological activity of IL-33 PMID: 18450470
an isoform of the IL-1 receptor accessory protein (termed AcPb) was identified that is expressed exclusively in the CNS. PMID: 19481478

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Subcellular Location

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.

Protein Families

Interleukin-1 receptor family

Tissue Specificity

Detected in lung, brain, spleen, thymus and liver. Expressed in brain endothelial cells, astrocytes, microglia and neurons. Isoform 3 is predominantly expressed in brain; expressed in hippocampal neurons.

Database Links

KEGG: mmu:16180

UniGene: Mm.253424

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Related pathways

MAPK signaling pathway Th17 cell differentiation

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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