IL-1 RAP, known as interleukin-1 receptor accessory protein (IL-1RAcP), is a crucial component of the IL-1 signaling pathway. It enhances IL-1 signaling by binding to the IL-1 receptor. This interaction activates downstream inflammatory pathways and regulates immune cell activity and inflammatory responses. IL-1 RAP plays a significant role in immune regulation, cell proliferation, and differentiation, with abnormal expression linked to various diseases, including cancer and autoimmune disorders. Consequently, IL-1 RAP has emerged as a promising target for disease treatment, and therapies targeting it are gradually entering clinical trials. Ongoing research aims to uncover its specific mechanisms in tumor development and to explore new therapeutic strategies for effective disease management.
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human IL1RAP at 2 μg/ml can bind Anti-IL1RAP recombinant antibody (CSB-RA878844MA1HU). The EC50 is 0.9667-1.477 ng/mL.
The purity of IL1RAP was greater than 95% as determined by SEC-HPLC
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis IL1RAP at 2 μg/ml can bind Anti-IL1RAP recombinant antibody (CSB-RA878844MA1HU). The EC50 is 0.9099-1.181 ng/mL.
The purity of IL1RAP was greater than 95% as determined by SEC-HPLC
The following IL1RAP reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
IL1RAP Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA878844ESR1HU | IL1RAP Antibody | Human | ELISA, IHC |
CSB-PA238165 | IL1RAP Antibody | Human,Mouse,Rat | ELISA,IHC |
IL1RAP Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-YP011623MOW1 CSB-EP011623MOW1 CSB-BP011623MOW1 CSB-MP011623MOW1 CSB-EP011623MOW1-B |
Recombinant Macaca mulatta (Rhesus macaque) Interleukin-1 receptor accessory protein (IL1RAP), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF011623MOW | Recombinant Macaca mulatta (Rhesus macaque) Interleukin-1 receptor accessory protein (IL1RAP) | in vitro E.coli expression system |
IL1RAP Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP730751MO CSB-EP730751MO CSB-BP730751MO CSB-MP730751MO CSB-EP730751MO-B |
Recombinant Mouse Interleukin-1 receptor accessory protein (Il1rap), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1RAP Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP733954RA CSB-BP733954RA CSB-MP733954RA CSB-EP733954RA-B |
Recombinant Rat Interleukin-1 receptor accessory protein (Il1rap), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1RAP Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP878844HU CSB-EP878844HU CSB-BP878844HU CSB-MP878844HU CSB-EP878844HU-B |
Recombinant Human Interleukin-1 receptor accessory protein (IL1RAP), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-MP878844HU | Recombinant Human Interleukin-1 receptor accessory protein (IL1RAP), partial (Active) | Mammalian cell |