IL1RAP Research Reagents

Interleukin-1 receptor accessory protein is a protein in humans that is encoded by IL1RAP gene. Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).

The following IL1RAP reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

IL1RAP Antibodies

IL1RAP Antibodies for Homo sapiens (Human)

IL1RAP Proteins

IL1RAP Proteins for Macaca mulatta (Rhesus macaque)

IL1RAP Proteins for Mus musculus (Mouse)

IL1RAP Proteins for Rattus norvegicus (Rat)

IL1RAP Proteins for Homo sapiens (Human)

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