Il1rl2 Recombinant Monoclonal Antibody

Datasheet

Code	CSB-RA875357MA1MO
Size	US$210
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Image	The Binding Activity of Mouse Il1rl2 with Anti-Il1rl2 Recombinant Antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Il1rl2 (CSB-MP875357MO) at 2 μg/mL can bind Anti-Il1rl2 recombinant antibody. The EC50 is 0.6983-1.037 ng/mL. The Binding Activity of Mouse Il1rl2 with Anti-IL1RL2 Recombinant Antibody Activity:IL1RL2 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Recombinant Mouse Il1rl2 (CSB-MP875357MO) protein with an affinity constant of 0.236 nM as detected by MetaSPR Assay (WeSPRTM 200).
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9ERS7

Target Names

Il1rl2

Alternative Names

Interleukin-1 receptor-like 2 (IL-36 receptor) (Interleukin-1 receptor-related protein 2) (IL-1Rrp2) (IL1R-rp2), Il1rl2

Species Reactivity

Mouse

Immunogen

Recombinant Mouse Il1rl2 protein

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

hIgG1

Clone No.

9E5

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, SPR

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:10000

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.

Gene References into Functions

IL-36R likely contributes to acute kidney injury pathogenesis through NF-kB activity and IL-6 and TNF-a upregulation. PMID: 29241623
these findings reveal a fundamental contribution for the IL-36/IL-36R axis in regulating the Treg-Th9 cell balance with broad implications for Th cell-mediated disorders, such as inflammatory bowel diseases and particularly ulcerative colitis PMID: 28327619
IL-36R-deficient mice were protected from influenza virus-induced lung injury and mortality PMID: 27966554
Data show that Interleukin-36 receptor (IL-36R)-deficient fibroblast-like synoviocytes (FLS) had a limited capacity to support plasma cells (PC) survival compared to wild-type FLS. PMID: 28857172

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Interleukin-1 receptor family

Tissue Specificity

Expressed in bone marrow-derived dendritic cells, splenic CD4(+) T-cells, bone marrow-derived macrophages and bone marrow-derived neutrophils.

Database Links

KEGG: mmu:107527

STRING: 10090.ENSMUSP00000092630

UniGene: Mm.155583

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Related pathways

Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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