Interleukin 1 receptor-like 2 (IL1RL2), also known as IL-36R, is a member of the IL-1R family. Among the IL-1R family members, IL1RL2 recognizes the largest number of agonists. IL-1RL2 was identified for the first time in rat and human cDNA as a novel gene encoding a receptor associated with IL-1R. The IL-1RL2 protein structure is divided into three parts, including extracellular, transmembrane and intracellular domains. Although IL-1RL2 is similar to other IL-1R family members and also contains 12 cysteine residues in the extracellular domain (ECD), Cys-154 and Cys-262 are unique to IL1RL2. The cytoplasmic domain of IL1RL2 is up to 50% identical to the cytoplasmic domain of IL-1R. Amino acids within the cytoplasmic domain are highly conserved, especially amino acids 507-522aa. IL-1RL2 is conserved in zebrafish, chimpanzees, rhesus monkeys, dogs, cows, mice and rats, as well as many other mammals. According to the Human Tissue Expression Database, IL1RL2 is expressed in the esophagus, gallbladder, liver, lung, prostate, skin, stomach and thyroid.
IL1RL2 is constitutively expressed in immune cells such as dendritic cells (DC), CD4+ T cells and macrophages, but not B cells or CD8+ T cells. IL1RL2 is expressed in human peripheral blood lymphocytes. CD4+ T cells localize the receptor to a large cytoplasmic depot, CD8+ T cells localize the receptor to the membrane, and B cells show a small accumulation of the receptor in the cytoplasmic depot.
The following IL1RL2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
IL1RL2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA888016LA01HU | IL1RL2 Antibody |
Human | ELISA, IHC |
CSB-PA888016LB01HU | IL1RL2 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA888016LC01HU | IL1RL2 Antibody, FITC conjugated |
Human | |
CSB-PA888016LD01HU | IL1RL2 Antibody, Biotin conjugated |
Human | ELISA |
IL1RL2 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA875357ZA01MO | Il1rl2 Antibody |
Mus musculus | ELISA, WB (ensure identification of antigen) |
IL1RL2 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP714040RA CSB-EP714040RA CSB-BP714040RA CSB-MP714040RA CSB-EP714040RA-B |
Recombinant Rat Interleukin-1 receptor-like 2 (Il1rl2), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1RL2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP875357MO CSB-BP875357MO CSB-MP875357MO CSB-EP875357MO-B |
Recombinant Mouse Interleukin-1 receptor-like 2 (Il1rl2), partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP875357MO | Recombinant Mouse Interleukin-1 receptor-like 2 (Il1rl2), partial |
E.coli |
IL1RL2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP888016HU CSB-EP888016HU CSB-BP888016HU CSB-MP888016HU CSB-EP888016HU-B |
Recombinant Human Interleukin-1 receptor-like 2 (IL1RL2), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP004541HU | Recombinant Human Interleukin-1 receptor-like 2 (IL1RL2), partial (Active) |
Mammalian cell |