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| Code | CSB-RA984568A0HU |
| Size | US$210 |
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| Application | Recommended Dilution |
|---|---|
| WB | 1:500-1:2000 |
| IHC | 1:50-1:200 |
| FC | 1:50-1:200 |
The MAPK1/MAPK3 recombinant monoclonal antibody is produced using in vitro expression systems. The expression systems are developed by cloning the MAPK1/MAPK3 antibody DNA sequences from immunoreactive rabbits. The immunogen is a synthesized peptide derived from the human MAPK1/MAPK3 protein. Then, the MAPK1/MAPK3 antibody genes are inserted into plasmid vectors. The recombinant plasmid vectors are transfected into host cells for antibody expression. The MAPK1/MAPK3 recombinant monoclonal antibody undergoes affinity-chromatography purification and is tested in ELISA, WB, IHC, and FC applications. It reacts with both human and mouse MAPK1/MAPK3 proteins.
MAPK1 (ERK2) and MAPK3 (ERK1) are both serine/threonine kinases and are highly homologous and often have overlapping functions. Once activated by extracellular signals, such as growth factors, cytokines, and mitogens, MAPK1 and MAPK3 phosphorylate a variety of downstream target proteins, including transcription factors and other kinases, thus triggering cascade events that promote cell proliferation, regulate cell cycle progression, and participate in cell differentiation and survival.
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