Code | CSB-RA799368A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
The process of manufacturing the MFN2 recombinant antibody consists of four steps. Firstly, the MFN2 monoclonal antibody gene is sequenced, followed by cloning the gene into a plasmid vector. Next, the recombinant vector is introduced into a host cell line, after which the MFN2 recombinant monoclonal antibody is purified from the cell culture supernatant using affinity chromatography. The MFN2 monoclonal antibody is derived from the MFN2 antibody-producing hybridomas, with a synthesized peptide from human MFN2 being used as the immunogen during the production process. This MFN2 recombinant monoclonal antibody is highly recommended for use in detecting human MFN2 protein in ELISA and IHC applications.
MFN2 is a transmembrane protein that resides in the outer mitochondrial membrane, where it plays a key role in the fusion of mitochondria. MFN2 interacts with its homolog MFN1 on the outer mitochondrial membrane of adjacent mitochondria, leading to the tethering and fusion of the organelles. This process is critical for the maintenance of mitochondrial integrity, the distribution of mitochondrial DNA, and the regulation of cellular metabolism. MFN2 has also been implicated in a variety of cellular processes, including apoptosis, autophagy, and cellular metabolism. The dysregulation of MFN2 has been linked to a variety of diseases, including neurological disorders, metabolic disorders, and cardiovascular disease.
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