MFN2

Mitofusin-2 (MFN2), alias MARF or HMSN6, is a mitochondrial outer membrane GTPase essential for mediating mitochondrial fusion. It shapes mitochondrial networks, sustains oxidative phosphorylation efficiency, and modulates cell apoptosis via interactions with MFN1. Additionally, MFN2 tethers mitochondria to the endoplasmic reticulum, facilitating calcium signaling and lipid exchange.
Mutations in MFN2 cause Charcot-Marie-Tooth disease type 2A2 (CMT2A2), a peripheral neuropathy. Dysregulation links to insulin resistance, Parkinson’s disease, and heart failure. Preclinical studies focus on small molecules targeting MFN2 to restore fusion; candidates show promise in ameliorating metabolic and neurodegenerative phenotypes, though no approved therapies exist currently.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

MFN2 Recombinant Monoclonal Antibody (CSB-RA799368A0HU)

Validated Data

IHC image of CSB-RA799368A0HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

MFN2 Antibody (CSB-PA013756LA01HU)

Validated Data

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA013756LA01HU at dilution of 1:100

Western Blot
Positive WB detected in: Rat kidney tissue
All lanes: MFN2 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 89, 51 kDa
Observed band size: 89 kDa

The following MFN2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

MFN2 Antibodies

MFN2 Proteins

MFN2 Antibodies

MFN2 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA013756GA01HU	MFN2 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA003234	MFN2 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA013756LA01HU	MFN2 Antibody	Human, Rat	ELISA, WB, IHC
CSB-PA013756LB01HU	MFN2 Antibody, HRP conjugated	Human	ELISA
CSB-PA013756LC01HU	MFN2 Antibody, FITC conjugated	Human
CSB-PA013756LD01HU	MFN2 Antibody, Biotin conjugated	Human	ELISA
CSB-RA799368A0HU	MFN2 Recombinant Monoclonal Antibody	Human	ELISA, IHC

MFN2 Proteins

MFN2 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF770460MO	Recombinant Mouse Mitofusin-2 (Mfn2)	in vitro E.coli expression system
CSB-YP770460MO1 CSB-BP770460MO1 CSB-MP770460MO1 CSB-EP770460MO1-B	Recombinant Mouse Mitofusin-2 (Mfn2), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MFN2 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF837154RA	Recombinant Rat Mitofusin-2 (Mfn2)	in vitro E.coli expression system
CSB-YP837154RA1 CSB-EP837154RA1 CSB-BP837154RA1 CSB-MP837154RA1 CSB-EP837154RA1-B	Recombinant Rat Mitofusin-2 (Mfn2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MFN2 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF013756HU	Recombinant Human Mitofusin-2 (MFN2)	in vitro E.coli expression system
CSB-YP013756HU1 CSB-EP013756HU1 CSB-BP013756HU1 CSB-EP013756HU1-B	Recombinant Human Mitofusin-2 (MFN2), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP013756HU	Recombinant Human Mitofusin-2 (MFN2)-VLPs	Mammalian cell
CSB-MP013756HU1	Recombinant Human Mitofusin-2 (MFN2), partial	Mammalian cell

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MFN2

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