PTGS2 Antibody

Datasheet
Code CSB-RA018986A0HU
Size US$350
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Product Details

Uniprot No. P35354
Target Names PTGS2
Alternative Names COX 2 antibody; COX-2 antibody; COX2 antibody; Cyclooxygenase 2 antibody; Cyclooxygenase 2b antibody; Cyclooxygenase antibody; Cyclooxygenase-2 antibody; Cyclooxygenase2 antibody; EC 1.14.99.1 antibody; fj02a10 antibody; Glucocorticoid-regulated inflammatory cyclooxygenase antibody; Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase antibody; GRIPGHS antibody; hCox 2 antibody; Macrophage activation-associated marker protein P71/73 antibody; OTTHUMP00000033524 antibody; PES-2 antibody; PGG/HS antibody; PGH synthase 2 antibody; PGH2_HUMAN antibody; PGHS 2 antibody; PGHS-2 antibody; PGHS2 antibody; PHS 2 antibody; PHS II antibody; PHS2 antibody; Prostaglandin endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) antibody; Prostaglandin endoperoxide synthase 2 antibody; Prostaglandin G/H synthase 2 antibody; Prostaglandin G/H synthase 2 precursor antibody; Prostaglandin G/H synthase and cyclooxygenase antibody; Prostaglandin G/H synthase antibody; Prostaglandin H2 synthase 2 antibody; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) antibody; Prostaglandin-endoperoxide synthase 2 antibody; PTGS2 antibody; ptgs2a antibody; TIS10 antibody; TIS10 protein antibody; unp1239 antibody; wu:fj02a10 antibody
Species Reactivity Human
Immunogen A synthesized peptide derived from human PTGS2
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Monoclonal
Isotype Rabbit IgG
Purification Method Affinity-chromatography
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
Gene References into Functions
  1. SND1 may act as a potential biomarker of the therapeutic strategies utilizing COX2 inhibitors. PMID: 30365124
  2. Authors showed that mRNA and protein levels of COX2 and HER2 were upregulated in CRC compared with the adjacent tissues. COX2 protein levels and nuclear COX2 expression were correlated with a poor prognosis of CRC patients. COX2 expression was positively associated with HER2 expression. PMID: 29873317
  3. PTGS2 polymorphisms were associated with advanced liver fibrosis in patients with HCV mono-Infection and HCV/HIV Co-Infection. PMID: 30139224
  4. An unrecognized cellular interaction between follicular dendritic cells and B cells leading to COX-2 expression during immune inflammatory responses. PMID: 29241029
  5. Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in Alzheimer's disease patients and in a transgenic mouse model. PMID: 29662056
  6. miR-137 suppresses the proliferation and invasion of retinoblastoma cells by targeting COX-2/PGE2 signaling pathway. PMID: 29945115
  7. Dual governing of YAP and COX-2 may lead to the discovery of promising therapeutic strategies for HCC patients. PMID: 29505957
  8. COX-2 expression was positively associated with the recurrence and a poor prognosis of patients with nasopharyngeal carcinoma. PMID: 29956730
  9. COX-2 is an important factor for Dengue virus replication. PMID: 28317866
  10. Lysophosphatidylcholine induces COX-2-mediated IL-6 expression. NADPH oxidase/Reactive Oxygen Species is involved in Lysophosphatidylcholine-induced COX-2 expression. PMID: 30229288
  11. results support a critical role of ATF6alpha in the establishment and maintenance of cellular senescence in normal human fibroblasts via the up-regulation of a COX2/PGE2 intracrine pathway. PMID: 28803844
  12. High PTGS2 expression is associated with Breast Carcinoma. PMID: 30051683
  13. concluded that COX-2 gene rs5275 variant contributes to Nasopharyngeal carcinoma risk in a Chinese population PMID: 30087034
  14. COX2 and YAP1 signaling pathways are connected with each other to induce SOX2 expression, cancer stem cell enrichment, and acquired resistance to chemotherapy in urothelial carcinoma of the bladder. PMID: 29180467
  15. No significant association between COX-2 8473 T > C polymorphism and cancer risk was detected. PMID: 30143023
  16. The results revealed that TLR4 and COX-2 were upregulated in PCa tissues; silencing of TLR4 or COX-2 inhibited PCa cell proliferation, migration, and invasion. PMID: 30098292
  17. Results describe a novel role for cyclooxygenase-2 (COX-2) in mediating the TGFbeta effects on breast cancer stem cells (BCSC) properties and imply that targeting the COX-2 pathway may prove useful for the treatment of triple-negative breast cancer by eliminating BCSCs. PMID: 28054666
  18. the effects of miR-101 inhibition on tumor growth were suppressed by COX-2 inhibition. PMID: 29404887
  19. Low PTGS2 expression is associated with Invasive Breast Carcinoma. PMID: 28808873
  20. rs2243250 (IL4) and rs5275 (PTGS2) were found to be significantly associated with shorter renal cell cancer-specific survival (CSS). PMID: 28117391
  21. meta-analysis demonstrated that COX-2 rs5275 and rs689466 polymorphism significantly decrease the risk of lung cancer in Asians but not in Caucasians, indicating COX-2 could serve as a potential diagnostic marker for lung cancer PMID: 30170377
  22. meta-analysis of association between 765G/C polymorphism and periodontitis in Chinese population PMID: 29514641
  23. Through downregulation of COX-2 expression in SGC-7901 and MGC-803 cells. PMID: 29901169
  24. Patients with a high expression of COX-2 in baseline tumor biopsies had less response to treatment of pathology compared to patients with lower expression of COX-2 in baseline tumor biopsies. PMID: 29893307
  25. Studied the association between integrin subunit alpha 2 (GPIa) and prostaglandin-endoperoxide synthase 2 (COX-2) genetic polymorphisms in Chinese ishemic stroke patients with or without aspirin resistance. PMID: 28948649
  26. COX-2 was significantly associated with a lower 5-year disease-free survival (DFS) rate PMID: 29559247
  27. The polymorphism in the COX2 gene is associated with increased susceptibility to colorectal cancer, specially rectosigmoid tumors PMID: 29257846
  28. demonstrate the unregulated expression of ANXA1 and COX-2 in precursor lesions of esophageal and stomach cancers PMID: 29254791
  29. The cytotoxicity induced by EB1 gene knockdown was due to the activation and generation of reactive oxygen species by p38 mitogen-activated protein kinase..this signaling cascade, however not nuclear factor-kappaB-mediated signaling, induced the expression of cyclooxygenase-2, a key effector of apoptotic death. PMID: 29484424
  30. High COX2 expression is associated with Ras and BRAF mutations in Hepatocellular Carcinoma. PMID: 28188432
  31. High COX2 expression is associated with ovarian cancer cell migration and invasion. PMID: 28677781
  32. hypothesize that lower transcript levels of PTGS2 in cumulus cells may be involved in the impairment of oocyte quality, suggesting a possible mechanism involved in disease-related infertility PMID: 28734688
  33. Results suggest that a significant correlation exists in Japan between the COX-2 1195 G-carrier genotype and intestinal metaplasia in histological and endoscopic findings based on Kyoto classification in H. pylori-infected gastric mucosa. PMID: 28946145
  34. activated Ras, protumorigenic COX-2 and Notch1 have roles in in papillary mucinous neoplasm onset PMID: 27381829
  35. TGF-beta1 increased the COX-2 and PGE2 level of cultured pulp cells. The effect of TGF-beta1 on COX-2 protein expression was associated with ALK5/Smad2/3 and MEK/ERK pathways. PMID: 28779848
  36. Culinary herbs and spices prevent the growth of HCA-7 colorectal adenocarcinoma cancer cells and inhibit their COX-2 expression. PMID: 28934138
  37. medical use of COX inhibitors in glioblastoma treatment has been limited due to their well-documented vascular toxicity and inconsistent outcomes from recent human studies. Prostaglandin E2 (PGE2) has emerged as a principal mediator for COX-2 cascade-driven gliomagenesis PMID: 28718447
  38. COX2 inversely regulated Notch1 in gastric cancer and partially depended on the Notch1 signalling pathway in altering the expression of Snail. PMID: 28586004
  39. Based on the contribution maps from the three techniques, it can be concluded that both the benzenesulfonyl group and the central five-membered ring - having a high-electronegativity functional group or atom or having a substituent hydrogen bonding acceptor - contribute positively to the selective inhibition of COX-2 PMID: 27145042
  40. Findings demonstrate that COX-2 and p-Akt1 play an important combined role during melanoma progression and are associated with highly metastatic tumors and survival rates in patients with MM. PMID: 28604419
  41. Results suggest that higher COX-2 expression may be a negative prognostic factor in conjunctival melanoma. Further studies can address the potential use of anti-COX-2 drugs as adjuvant therapy of this disease. PMID: 29297092
  42. activation of ERK1/2 signaling was required for hCG-induced up-regulation of SPRY2 expression. Further, SPRY2 knockdown attenuated the AREG-induced COX-2 expression and PGE2 production by inhibiting AREG-activated ERK1/2 signaling. PMID: 27539669
  43. COX-2 was elevated in glioma tissues and its expression was negatively correlated with the levels of miR-128. These findings may establish miR-128 as a new potential target for the treatment of patients with gliomas. PMID: 29524580
  44. Post-transcriptional regulation of COX-2 mRNAs translation by SGs indicates a role in IL-1beta-mediated catabolic response that could be therapeutically targeted in Osteoarthritis. PMID: 27271770
  45. Results show that in influenza A viruses (IAV)-infected cells, COX-2 expression is regulated. While the protein is induced at early time of infection, via recognition of IAV vRNA by RIG-I, COX-2 expression is reduced again during on-going replication due to destabilization of its mRNA by IAV-induced TTP. PMID: 27265729
  46. Our results highlight the role of COX-2 in constitutive IDO1 expression by human tumors and substantiate the use of COX-2 inhibitors to improve the efficacy of cancer immunotherapy, by reducing constitutive IDO1 expression, which contributes to the lack of T-cell infiltration in "cold" tumors, which fail to respond to immunotherapy PMID: 28765120
  47. Chinese population with GG genotype of COX-2 gene polymorphism rs689466 have higher risk to develope post-traumatic osteomyelitis. PMID: 28682162
  48. 4-Hydroxy-2-nonenal is a natural inducer of COX-2 in atherosclerosis. (Review) PMID: 28192229
  49. RhoA and COX-2 were upregulated in early gastric cancer tissues, which facilitated the proliferation and migration of gastric cancer cells. PMID: 28624843
  50. LXR gene expression was significantly increased in obese children with obstructive sleep apnea-hypopnea syndrome (OSAHS). The severity of OSAHS was positively correlated with COX-2 levels. PMID: 28676625
  51. COX-2, GREM1, and HAS2 are cumulus cell genes that potentially determine oocyte and embryo developmental competence. (Review) PMID: 29537212
  52. The expression of Ki-67, PSCA, and Cox-2 biomarkers along with other clinicopathologic factors were prognostic factors for biochemical recurrence in patients with clinically localized prostate cancer following radical prostatectomy PMID: 27232854
  53. provided a novel method to isolate trCOX-2 possessing AA binding and catalytic activities. This study thus lays a foundation to facilitate further investigations of COX-2 and offers a valuable method with which to achieve the prokaryotic expression of a eukaryotic membrane protein. PMID: 28560423
  54. COX-2 has been found to be overexpressed in Sinonasal Inverted Papilloma , and most likely plays an important role in the process of malignant transformation from Sinonasal Inverted Papilloma to Squamous Cell Carcinoma. PMID: 28432463
  55. Expression of COX-2 in adenocarcinomas of the esophagogastric junction seems to have no prognostic effect or impact on patients' survival but is associated with favourable clinicopathologic factors PMID: 27854106
  56. Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-kappaB signaling pathway in keratinocytes. PMID: 28330776
  57. the present study identified a positive correlation between EpCAM and COX-2 expression in breast cancer cell lines and tissue specimens. EpCAM and COX-2 were associated with the prognosis of breast cancer patients. PMID: 28393249
  58. Tumor-infiltrating M2 macrophages could induce vasculogenic mimicry by up-regulating COX-2 expression in glioblastoma multiforme cells. PMID: 27824617
  59. The results of this study show suppression of COX-2 in gingival tissue after low-level laser treatment as adjunct to scaling and root planing. PMID: 28523391
  60. cyclooxygenase-2 is differentially expressed in metastatic melanoma, which has a role in progression free survival PMID: 27494851
  61. Results show that overexpression of Aurora-A and PTGS2 occurs in colon polyps and has a reverse correlation with miR-137 in both colon polyps and colorectal cancer tissue suggesting that AURKA and PTGS2 expression is under the regulation of mir-137. PMID: 27764771
  62. Studied role of HPV16 E6 and COX-2 in invasive ductal breast cancer using qPCR and IHC, and in vitro studies. Found HPV16 E6 promoted breast cancer proliferation; Cox-2 inhibition suppressed HPV16 E6 effects on proliferation thru NF-kappaB signaling pathway. PMID: 29250535
  63. reviews the cardiovascular effects of COX-2 inhibitors with a focus on the mechanisms contributing to the clinical readouts of COX-2 inhibition. PMID: 27317138
  64. Colorectal carcinoma harboring ALK fusions represent a rare aggressive subtype of colorectal carcinoma with distinct clinicopathologic features. This report provides the first clinical evidence that such patients may benefit from targeted monotherapy with ALK inhibitors. PMID: 26957558
  65. This finding may provide a new option besides COX inhibition to optimize cancer therapy. The outcome of this translational research will guide us to develop a novel omega-6-based diet-care strategy in combination with current chemotherapy for colon cancer prevention and treatment. PMID: 27101738
  66. sUV activated the transcription factors nuclear factor-kappaB and activator protein-1 which, in turn, induces COX-2 expression. PMID: 28409880
  67. A single SNP (rs689466) localized at 5' -1192 of the PTGS2 gene exhibited significant association with febrile seizure (FS) based on case-control allelic association analyses. A significant decrease in the frequency of the G allele in FS was observed compared to that in controls. Using case-control genotypic association analysis, the -1192A allele is most likely to confer susceptibility to FS by a recessive action model. PMID: 27871023
  68. The anticancer effects by 13'-COOHs appeared to be partially independent of inhibition of COX-2/5-LOX. Using liquid chromatography tandem mass spectrometry, we found that 13'-COOHs increased intracellular dihydrosphingosine and dihydroceramides after short-time incubation in HCT-116 cells, and enhanced ceramides while decreased sphingomyelins during prolonged treatment PMID: 27016075
  69. Effects of pro-inflammatory cytokines, lipopolysaccharide and COX-2 mediators on human colonic neuromuscular function and epithelial permeability PMID: 27177092
  70. High PTGS2 expression is associated with metastasis of esophageal squamous cell cancer. PMID: 26959737
  71. Rs20417CC is not only independent risk factor for symptomatic carotid artery or intracranial arterial stenosis, but is also independent risk predictor for neurologic deterioration in ischemic stroke patients. PMID: 28108096
  72. Experimental results indicate that methylmercury inhibits the activity of protein tyrosine phosphatase 1B, which in turn activates the epidermal growth factor receptor-p38 mitogen-activated protein kinase pathway that induces cyclooxygenase-2 expression. PMID: 28958600
  73. Our data suggest that the molecular network including TSP-1, TGF-beta1, and PGE2 might be involved in the pathogenesis of acute angle closure glaucoma. PMID: 28323501
  74. the COX-2 -1195G>A gene polymorphism might be a potential risk factor for gastrointestinal cancers [review] PMID: 28405152
  75. we demonstrated that we could take the advantage of the common phenomenon of COX-2 overexpression in cancers to inhibit cancer cell migration and invasion PMID: 28157665
  76. that a genetically modulated balancing of signaling within the CB1-COX-2 pathway may reflect on more or less efficient patterns of prefrontal activity during working memory PMID: 27261878
  77. Diabetes and cardiopulmonary bypass are associated with upregulation in COX-2 expression/activation in peripheral microvasculature. PMID: 28985857
  78. COX-2 directly oxidizes 2-arachidonoyl-lysophospholipids to eicosanoid-lysolipids. PMID: 27642067
  79. COX-2 expression correlates with and modulates PD-L1 expression in melanoma cells. PMID: 28231855
  80. PTGS2 rs20417CC genotype is associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients. PMID: 28704403
  81. Current results suggest that COX-2 rs689466, rs5275, and rs20417 polymorphisms are not associated with head and neck squamous cell carcinoma.[meta-analysis] PMID: 27412115
  82. Specific inhibitors of COX-2 and 5-LOX decreased formation of HKD2 and HKE2 Platelets did not form HKs from exogenous 5S-hydroxyeicosatetraenoic acid, implying that COX-1 is not involved PMID: 28096231
  83. Leptin induced COX-2 expression, promoter activity, and increased the production of prostaglandin E2. PMID: 28571770
  84. AhR controls COX-2 protein via mRNA stability. PMID: 28749959
  85. data expand upon the roles of COX-2 in shaping the structure and function of the extracellular matrix in primary and metastatic tumors PMID: 28152501
  86. a stiffness-dependent YAP/TAZ-mediated positive feedback loop that drives remodeling phenotypes in pulmonary artery smooth muscle cells via reduced COX-2 and prostaglandin activity. PMID: 28642262
  87. Human apoA-I was overexpressed by transfection in BEL-7402 hepatocytes and by an adenoviral vector in C57BL/6J mice fed a methionine choline-deficient diet. The overexpression of apoA-I in both models resulted in decreased reactive oxygen species and lipid peroxidation levels, as well as a reduced MAPK phosphorylation and decreased expression levels of c-Fos and COX-2. PMID: 25451254
  88. higher COX-2 expression levels in biopsy specimens may be used to decide re-biopsy in borderline preoperative PSA levels as well as in the cases with suspicious pathological findings for cancer PMID: 26125280
  89. short hairpin-mediated silencing of SEMA7A reveals roles for semaphorin 7a in the promotion of DCIS growth, motility and invasion as well as lymphangiogenesis in the tumor microenvironment. Our studies also uncover a relationship between COX-2 and semaphorin 7a expression and suggest that semaphorin 7a promotes tumor cell invasion on collagen and lymphangiogenesis via activation of b1-integrin receptor PMID: 27065336
  90. Bisphenol A (BPA) induced COX-2 expression via nuclear translocation of NF-kappaB and activation of mitogen-activated protein kinase (MAPK) by phosphorylation of ERK1/2 and enhanced the migration of lung cancer A549 and breast cancer MDAMB-231 cells. PMID: 28709031
  91. Data show that in colorectal cancer SerpinB3, COX-2 and beta-Catenin are positively correlated and associated with more advanced tumor stage. PMID: 28178650
  92. Ibuprofen binding to Eallo of huPGHS-2 completely blocks 2-AG or 2-AG ether oxygenation; however, inhibition by ibuprofen of huPGHS-2-mediated oxygenation of AA engages a combination of both allosteric and competitive mechanisms PMID: 27059979
  93. Higher proliferation rate of NKT cells was also observed in non-metastatic and highly differentiated Laryngeal Cancer( LC), which was independent of the type of stimulation or treatment. COX-2 inhibition could be regarded as immunotherapy-enhancing tool in patients with LC. PMID: 28739688
  94. Data indicate that ellagic aicd (EA) down-regulates the expression of COX-2, NF-kappa B, vimentin and up-regulates the expression of E-cadherin in in pancreatic carcinom PANC-1 cells. PMID: 28135203
  95. YAP function is required for NF2-null Schwann cell survival, proliferation, and tumor growth in vivo Moreover, YAP promotes transcription of several targets including PTGS2, which codes for COX-2, a key enzyme in prostaglandin biosynthesis, and AREG, which codes for the EGFR ligand, amphiregulin. PMID: 27216189
  96. The aspirin-mediated inactivation of platelets may restore antitumor reactivity by blocking the release of paracrine lipid and protein mediators that induce COX-2 expression in adjacent nucleated cells at sites of mucosal injury. [review] PMID: 27344083
  97. HULC enhanced the level of ubiquitin-specific peptidase 22 (USP22), which decreased ubiquitin-mediated degradation of COX-2 protein by removing the conjugated polyubiquitin chains from COX-2 and finally stabilized COX2 protein. PMID: 28634076
  98. COX-2 expression was significantly increased in wound edge amniotic membrane after fetoscopy compared with controls. PMID: 27568096
  99. Cleavage and polyadenylation specific factor 4 targets NF-kappaB/cyclooxygenase-2 signaling to promote the growth and survival of non-small cell lung carcinoma cells. PMID: 27450326
  100. we aimed to determine the mechanism of action of FIN and found that FIN induced the expansion of MDSCs through up-regulation of the COX2/PGE2 pathway by enhancing the activity of COX2 promoter. In addition, the administration of indomethacin (IND), a COX2 inhibitor, abrogated the effect of FIN. PMID: 27253400

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Subcellular Location Microsome membrane, Peripheral membrane protein, Endoplasmic reticulum membrane, Peripheral membrane protein
Protein Families Prostaglandin G/H synthase family
Database Links

HGNC: 9605

OMIM: 600262

KEGG: hsa:5743

STRING: 9606.ENSP00000356438

UniGene: Hs.196384

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