PTGS2, prostaglandin endoperoxide synthase 2, is also known as cyclooxygenase-2 (COX-2). It is an enzyme expressed in a variety of cell types, especially at increased levels during inflammation and tissue injury.The mechanism of action of PTGS2 is through the catalytic conversion of arachidonic acid to prostaglandin H2, which in turn is involved in a variety of physiological and pathological processes, including inflammatory responses, pain perception, fever, and platelet aggregation.The signalling pathways activated by PTGS2 involve NMDA receptor-dependent neurotransmitter release, cell proliferation, and cell survival. Biologically, PTGS2 not only plays a role in the maintenance of normal physiological functions, but also in tumour development, neurological injury and inflammatory diseases. Its aberrant expression has been associated with a variety of diseases including cancer, neurodegenerative diseases and cardiovascular diseases, and is a key regulatory point in many pathological processes.
Recombinant Human Prostaglandin G/H synthase 2 (PTGS2), partial (CSB-EP018986HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP018986HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) PTGS2.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP018986HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) PTGS2.
PTGS2 Recombinant Monoclonal Antibody (CSB-RA920283A0HU)
Validated Data
Western Blot
Positive WB detected in: U-87 whole cell lysate
All lanes: COX2 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 69 kDa
Observed band size: 69 kDa
Immunofluorescence staining of HepG2 Cells with CSB-RA920283A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
The following PTGS2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
PTGS2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA015073GA01HU | PTGS2 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA018986GA01HU | PTGS2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA997318 | PTGS2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-MA000320 | PTGS2 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA000361 | PTGS2 Antibody | Human | WB |
CSB-PA001764 | PTGS2 Antibody | Human | WB, IHC, IF, ELISA |
CSB-PA217397 | PTGS2 Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA184426 | PTGS2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-RA018986A0HU | PTGS2 Recombinant Monoclonal Antibody | Human | ELISA |
CSB-PA018986LA01HU | PTGS2 Antibody | Human | ELISA, WB |
CSB-PA018986LB01HU | PTGS2 Antibody, HRP conjugated | Human | ELISA |
CSB-PA018986LC01HU | PTGS2 Antibody, FITC conjugated | Human | |
CSB-PA018986LD01HU | PTGS2 Antibody, Biotin conjugated | Human | ELISA |
CSB-RA920283A0HU | PTGS2 Recombinant Monoclonal Antibody | Human | ELISA, WB, IF |
PTGS2 Proteins for Ovis aries (Sheep)
Code | Product Name | Source |
---|---|---|
CSB-YP018986SH CSB-EP018986SH CSB-BP018986SH CSB-MP018986SH CSB-EP018986SH-B |
Recombinant Sheep Prostaglandin G/H synthase 2 (PTGS2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTGS2 Proteins for Cavia porcellus (Guinea pig)
Code | Product Name | Source |
---|---|---|
CSB-YP018986GU CSB-EP018986GU CSB-BP018986GU CSB-MP018986GU CSB-EP018986GU-B |
Recombinant Guinea pig Prostaglandin G/H synthase 2 (PTGS2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTGS2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP018986HU CSB-BP018986HU CSB-MP018986HU CSB-EP018986HU-B |
Recombinant Human Prostaglandin G/H synthase 2 (PTGS2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP018986HU | Recombinant Human Prostaglandin G/H synthase 2 (PTGS2), partial | E.coli |
PTGS2 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP018986CH CSB-EP018986CH CSB-BP018986CH CSB-MP018986CH CSB-EP018986CH-B |
Recombinant Chicken Prostaglandin G/H synthase 2 (PTGS2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTGS2 Proteins for Oryctolagus cuniculus (Rabbit)
Code | Product Name | Source |
---|---|---|
CSB-YP018986RB CSB-EP018986RB CSB-BP018986RB CSB-MP018986RB CSB-EP018986RB-B |
Recombinant Rabbit Prostaglandin G/H synthase 2 (PTGS2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTGS2 Proteins for Equus caballus (Horse)
Code | Product Name | Source |
---|---|---|
CSB-YP018986HO CSB-EP018986HO CSB-BP018986HO CSB-MP018986HO CSB-EP018986HO-B |
Recombinant Horse Prostaglandin G/H synthase 2 (PTGS2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTGS2 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP018986BO CSB-EP018986BO CSB-BP018986BO CSB-MP018986BO CSB-EP018986BO-B |
Recombinant Bovine Prostaglandin G/H synthase 2 (PTGS2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTGS2 Proteins for Neovison vison (American mink) (Mustela vison)
Code | Product Name | Source |
---|---|---|
CSB-YP018986MVE CSB-EP018986MVE CSB-BP018986MVE CSB-MP018986MVE CSB-EP018986MVE-B |
Recombinant Mustela vison Prostaglandin G/H synthase 2 (PTGS2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTGS2 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP018986RA CSB-EP018986RA CSB-BP018986RA CSB-MP018986RA CSB-EP018986RA-B |
Recombinant Rat Prostaglandin G/H synthase 2 (Ptgs2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTGS2 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E10103h | Human cyclooxygenase-2,COX-2 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.31 ng/mL |
PTGS2 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E12910m | Mouse cyclooxygenase-2,COX-2 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 7.8 pg/mL |
PTGS2 ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E13399r | Rat cyclooxygenase-2,COX-2 ELISA Kit | serum, plasma, tissue homogenates | 0.39 ng/mL |