PTGS2

PTGS2, prostaglandin endoperoxide synthase 2, is also known as cyclooxygenase-2 (COX-2). It is an enzyme expressed in a variety of cell types, especially at increased levels during inflammation and tissue injury.The mechanism of action of PTGS2 is through the catalytic conversion of arachidonic acid to prostaglandin H2, which in turn is involved in a variety of physiological and pathological processes, including inflammatory responses, pain perception, fever, and platelet aggregation.The signalling pathways activated by PTGS2 involve NMDA receptor-dependent neurotransmitter release, cell proliferation, and cell survival. Biologically, PTGS2 not only plays a role in the maintenance of normal physiological functions, but also in tumour development, neurological injury and inflammatory diseases. Its aberrant expression has been associated with a variety of diseases including cancer, neurodegenerative diseases and cardiovascular diseases, and is a key regulatory point in many pathological processes.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP018986HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) PTGS2.

PTGS2 Recombinant Monoclonal Antibody (CSB-RA920283A0HU)

Validated Data

Western Blot
Positive WB detected in: U-87 whole cell lysate
All lanes: COX2 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 69 kDa
Observed band size: 69 kDa

Immunofluorescence staining of HepG2 Cells with CSB-RA920283A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

The following PTGS2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PTGS2 Antibodies

PTGS2 Proteins

PTGS2 ELISA Kits

PTGS2 Antibodies

PTGS2 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA015073GA01HU	PTGS2 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA018986GA01HU	PTGS2 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA997318	PTGS2 Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-MA000320	PTGS2 Monoclonal Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA000361	PTGS2 Antibody	Human	WB
CSB-PA001764	PTGS2 Antibody	Human	WB, IHC, IF, ELISA
CSB-PA217397	PTGS2 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA184426	PTGS2 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-RA018986A0HU	PTGS2 Recombinant Monoclonal Antibody	Human	ELISA
CSB-PA018986LA01HU	PTGS2 Antibody	Human	ELISA, WB
CSB-PA018986LB01HU	PTGS2 Antibody, HRP conjugated	Human	ELISA
CSB-PA018986LC01HU	PTGS2 Antibody, FITC conjugated	Human
CSB-PA018986LD01HU	PTGS2 Antibody, Biotin conjugated	Human	ELISA
CSB-RA920283A0HU	PTGS2 Recombinant Monoclonal Antibody	Human	ELISA, WB, IF

PTGS2 Proteins

PTGS2 Proteins for Ovis aries (Sheep)

Code	Product Name	Source
CSB-YP018986SH CSB-EP018986SH CSB-BP018986SH CSB-MP018986SH CSB-EP018986SH-B	Recombinant Sheep Prostaglandin G/H synthase 2 (PTGS2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTGS2 Proteins for Cavia porcellus (Guinea pig)

Code	Product Name	Source
CSB-YP018986GU CSB-EP018986GU CSB-BP018986GU CSB-MP018986GU CSB-EP018986GU-B	Recombinant Guinea pig Prostaglandin G/H synthase 2 (PTGS2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTGS2 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP018986HU CSB-BP018986HU CSB-MP018986HU CSB-EP018986HU-B	Recombinant Human Prostaglandin G/H synthase 2 (PTGS2), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP018986HU	Recombinant Human Prostaglandin G/H synthase 2 (PTGS2), partial	E.coli

PTGS2 Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP018986CH CSB-EP018986CH CSB-BP018986CH CSB-MP018986CH CSB-EP018986CH-B	Recombinant Chicken Prostaglandin G/H synthase 2 (PTGS2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTGS2 Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-YP018986RB CSB-EP018986RB CSB-BP018986RB CSB-MP018986RB CSB-EP018986RB-B	Recombinant Rabbit Prostaglandin G/H synthase 2 (PTGS2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTGS2 Proteins for Equus caballus (Horse)

Code	Product Name	Source
CSB-YP018986HO CSB-EP018986HO CSB-BP018986HO CSB-MP018986HO CSB-EP018986HO-B	Recombinant Horse Prostaglandin G/H synthase 2 (PTGS2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTGS2 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP018986BO CSB-EP018986BO CSB-BP018986BO CSB-MP018986BO CSB-EP018986BO-B	Recombinant Bovine Prostaglandin G/H synthase 2 (PTGS2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTGS2 Proteins for Neovison vison (American mink) (Mustela vison)

Code	Product Name	Source
CSB-YP018986MVE CSB-EP018986MVE CSB-BP018986MVE CSB-MP018986MVE CSB-EP018986MVE-B	Recombinant Mustela vison Prostaglandin G/H synthase 2 (PTGS2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTGS2 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP018986RA CSB-EP018986RA CSB-BP018986RA CSB-MP018986RA CSB-EP018986RA-B	Recombinant Rat Prostaglandin G/H synthase 2 (Ptgs2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli