Code | CSB-RA920283A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IF | 1:20-1:200 |
To produce the PTGS2 recombinant antibody, four steps are taken: sequencing the PTGS2 monoclonal antibody gene, cloning it into a plasmid vector, inserting the recombinant vector into a host cell line, and purifying the PTGS2 recombinant monoclonal antibody using affinity chromatography. The PTGS2 monoclonal antibody comes from the PTGS2 antibody-producing hybridomas and is produced using a synthesized peptide from human PTGS2 as an immunogen. The PTGS2 recombinant monoclonal antibody is useful for detecting human PTGS2 protein in ELISA, WB, and IF applications.
The PTGS2 protein, also known as cyclooxygenase-2 (COX-2), is an enzyme that plays a crucial role in the production of prostaglandins, which are hormone-like lipid compounds involved in various physiological and pathological processes, including inflammation, pain, and fever. PTGS2 is induced by various stimuli, such as cytokines, growth factors, and bacterial lipopolysaccharides, and catalyzes the conversion of arachidonic acid to prostaglandin H2 (PGH2). PGH2 is further metabolized by downstream enzymes to produce various prostaglandins, including prostaglandin E2 (PGE2), which is one of the most abundant and biologically active prostaglandins in the body. PGE2 has various physiological and pathological effects, including regulation of inflammation, immune response, and blood pressure.
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