Phospho-SMC1A (S957) Antibody

Datasheet
Code CSB-RA614804A957phHU
Size US$350
Uniprot No. Q14683
Image
  • Western Blot
    Positive WB detected in:293 whole cell lysate(treated with Calyculin A or not)
    All lanes:Phospho-SMC1A antibody at 1.11μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 160 KDa
    Observed band size: 160 KDa

Immunogen A synthesized peptide derived from Human Phospho-SMC1A (S957)
Species Reactivity Human
Tested Applications ELISA, WB; Recommended dilution: WB:1:500-1:5000
Relevance Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal
Alias Structural maintenance of chromosomes protein 1A, SMC protein 1A, SMC-1-alpha, Sb1.8, SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Research Area Cell Biology
Gene Names SMC1A
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
Involvement in disease Cornelia de Lange syndrome 2 (CDLS2)
Subcellular Location Nucleus, Chromosome, Chromosome, centromere, kinetochore
Protein Families SMC family, SMC1 subfamily
Database Links

HGNC: 11111

OMIM: 300040

KEGG: hsa:8243

STRING: 9606.ENSP00000323421

UniGene: Hs.211602

Pathway Cell cycle

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