RAB22A Recombinant Monoclonal Antibody

1. RAB22A is significantly upregulated in melanoma, plays an oncogenic role in the malignant phenotypes of melanoma cells, and its expression in melanoma is regulated by epigenetical mechanism. PMID: 27690221
2. that Rab22a enhances recycling of CD147, which is required for lung cancer cell migration and invasion PMID: 28433697
3. Rab3A-22A blocks exocytosis at a stage downstream intra-acrosomal calcium release. PMID: 27613869
4. RAB22A role in epithelial-mesenchymal transition of melanoma cells PMID: 27237979
5. the HOTAIR lncRNA positively regulated the protein expression of Rab22a through competition for miR-373 binding. the positive regulation between HOTAIR and Rab22a may be partially attributed to the ceRNA regulatory network via miR-373, indicating a potential therapeutic target for ovarian cancer. PMID: 27484896
6. miR-204 suppressed renal cell carcinoma proliferation and invasion by directly targeting the RAB22A gene. PMID: 26883716
7. Data show that Rab22a- and Rab5a-driven phagosomal uptake is a crucial step in the vesicular cascade that leads to elimination of spirochetes by macrophages. PMID: 26344766
8. our results demonstrated that miR-203 act as a tumor suppressor miRNA through regulating RAB22A expression and suggested its involvement in osteosarcoma progression and carcinogenesis. PMID: 26382657
9. Vaccinia virus traffics to early endosomes, where recycling endosome markers Rab11 and Rab22 are recruited to participate in subsequent virus trafficking prior to virus core uncoating in the cytoplasm. PMID: 26041286
10. these results demonstrate that miR-373 suppresses epithelial ovarian cancer invasion and metastasis by directly targeting Rab22a gene PMID: 25460499
11. Re-expression of miR-193b in breast cancer cell lines decreased DNAJC13 (HPS40) and RAB22A expression, providing a mechanism by which mir193-b acts as a tumor suppressor. PMID: 25550792
12. miR-204-5p acts as a tumor suppressor in colorectal cancer through inhibiting RAB22A and reveal RAB22A to be a new oncogene and prognostic factor for colorectal cancer. PMID: 25294901
13. Exposure of human breast cancer cells to hypoxia augments microvesicle (MVs) shedding that is mediated by the HIF-dependent expression of the small GTPase RAB22A, which colocalizes with budding MVs at the cell surface. PMID: 24938788
14. Data report the identification of Rab22 as a binding site on early endosomes for direct recruitment of Rabex-5 and activation of Rab5, establishing a Rab22-Rab5 signaling relay to promote early endosome fusion. PMID: 19759177
15. Rab22a may regulate the dynamic interactions of endosomal compartments and it may be involved in the communication between the biosynthetic and early endocytic pathways. PMID: 11870209
16. Rab22a regulates different steps in the recycling of cargo protein that has entered the cell independently of clathrin. PMID: 15181155
17. Rab22a can affect the trafficking from endosomes to the Golgi apparatus probably by promoting fusion among endosomes and impairing the proper segregation of membrane domains required for targeting to the trans-Golgi network (TGN). PMID: 15748882
18. Rab22a controls the transport of the transferrin receptor from sorting to recycling endosomes. PMID: 16537905

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HGNC: 9764

OMIM: 612966

KEGG: hsa:57403

STRING: 9606.ENSP00000244040

UniGene: Hs.529044