Code | CSB-RA212530A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
RPE65 is an isomerohydrolase expressed in the retinal pigment epithelium. It is important for the regeneration of the visual pigment required for both rod and cone vision. RPE65 is a retinoid isomerase that converts all-trans retinyl esters to 11-cis retinol and is engaged in the retinoid cycle, which continuously regenerates 11-cis retinal, the chromophore of rhodopsin. RPE65 is abundantly expressed in the retinal pigment epithelium (RPE) and is essential for optimal vision. Mutations in RPE65 are associated with inherited retinal diseases such as retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA).
The RPE65 antibody genes were cloned from B cells that were derived from immunized animals with A synthesized peptide derived from human RPE65 and then introduced into the plasma vectors, which were transfected into mammalian cell lines for up-scaling expression. The product was purified by A synthesized peptide derived from human RPE65 to obtain the recombinant antibody against RPE65. This recombinant RPE65 antibody is reactive with the RPE65 protein from Human. It is recommended for use in the ELISA, IHC.There are currently no reviews for this product.