SIN3A Recombinant Monoclonal Antibody

1. AML patients with high SIN3 A expression levels had a worse prognosis than those with low expression. The same Y325Cvariant seen in endometrial carcinoma was found in one AML patient. It was calculated to cause a predicted stability change of -1.433 Kcal/mol, indicating significant disruption of the secondary structure. PMID: 29764005
2. the FOXN3-NEAT1-SIN3A complex promotes epithelial-to-mesenchymal transition and invasion of breast cancer cells in vitro as well as dissemination and metastasis of breast cancer in vivo PMID: 28805661
3. Haploinsufficiency of SIN3A causes mild intellectual disability by affecting the development of cortical integrity. PMID: 27399968
4. Two novel translocations leading to the inactivation of RUNX1 and its partners SIN3A and TCF12 in myeloid leukemia. PMID: 26671595
5. Study suggests a lack of association of SIN3A gene sequence variants with azoospermia caused by Sertoli cell-only syndrome in humans. PMID: 25395209
6. down regulation of miR-202 increased the expression of its target Mxd1, followed by Mxd1 recruitment to the Sin3A repressor complex and through its dimerization with Max, and increased repression of Myc-Max target proteins. PMID: 25611699
7. protein pairs significantly correlated with an increased risk of death in non-small cell lung cancer: mSin3A with p16, and c-Myc with mSinA PMID: 26118188
8. Aberrantly expressed miR-210 regulates human U251 glioma cells apoptosis and proliferation partly through directly down-regulating SIN3A protein expression. PMID: 25481483
9. Bone-marrow-specific deletion of Sin3a, indicated that Sin3a-associated HDAC1/2-activity is essential for hematopoietic stem cell homeostasis. PMID: 24763403
10. SIN3A, generally regarded as a transcriptional repressor, is required for induction of gene transcription by the aryl hydrocarbon receptor. PMID: 25305016
11. EBNA3C binds strongly to BATF/IRF4/SPI1/RUNX3 sites to enhance transcription and recruits RBPJ/Sin3A- and REST/NRSF-repressive complexes to repress p14(ARF) and p16(INK4A) expression PMID: 24344258
12. reducing Sin3A strongly increased the invasive behavior of A549 human lung adenocarcinoma cells; findings show that Sin3A is downregulated in a variety of human tumors PMID: 22890320
13. The Sin3a complex acts as a context-dependent ISGF3/STAT3 transcriptional switch. PMID: 22783022
14. Ume6 is a negative regulator of ATG8 transcription, which acts along with a histone deacetylase complex including Sin3 and Rpd3 to regulate Atg8 levels PMID: 22733735
15. Interplay between SIN3A and STAT3 mediates chromatin conformational changes and GFAP expression during cellular differentiation.( PMID: 21779366
16. Sin3a, HDAC1, and YY1 are co-factors for Gon4l and that Gon4l may function as a platform for the assembly of complexes that regulate gene expression. PMID: 21454521
17. The study identifies Sin3A as a regulator of gene expression, survival, and growth in ERalpha-positive breast cancer cells. PMID: 20920219
18. sumoylation of ING2 enhances its binding to the Sin3A/HDAC complex and is required to regulate gene transcriptions PMID: 20676127
19. HDAC-Sin3A complex regulates LHR Gene transcription PMID: 12091390
20. Menin is important for recruiting an mSin3A-histone deacetylase complex to repress JunD transcriptional activity. PMID: 14559791
21. MeCP2 acts as a corepressor of PU.1 probably due to facilitating complex formation with mSin3A and HDACs. PMID: 14647463
22. transcription corepressor mSin3A interacts with SMN (Survival motor neuron) protein PMID: 14749338
23. Results suggest that SHP mediates recruitment of mSin3A-Swi/Snf to the CYP7A1 promoter, resulting in chromatin remodeling and gene repression. PMID: 15314177
24. p53 antagonizes c-Myb by recruiting mSin3A to down-regulate specific Myb target genes PMID: 15509555
25. Data indicate that T-bet can override repressive epigenetic modification through a T-box half-site and dissociation of the mSin3a corepressor from the promoter. PMID: 15684083
26. Sin3A-mediated deacetylation within the coding regions of active genes is directly linked to the histone methyltransferase activity of Smyd2 PMID: 16805913
27. Sin3A-mediated deacetylation within the coding regions of active genes is directly linked to the histone methyltransferase activity of Smyd2 [Symd2] PMID: 16805913
28. Repression of p53-mediated transcription by adenovirus E1B 55-kDa does not require corepressor mSin3A and histone deacetylases. PMID: 17209038
29. the attenuated function of SIN3A due to a decreased level of expression may result in epigenetic de-regulation of growth-related genes through histone acetylation, which leads to the tumorigenesis of lung cancer cells. PMID: 17854949
30. PRMT1- dependent methylation of RUNX1 at arginine residues 206 and 210 abrogates its association with SIN3A. PMID: 18316480
31. A novel regulatory signaling mechanism of transcriptional control in which the LHR is derepressed through PKCalpha/ERK-mediated Sp1 phosphorylation, causing the release of HDAC1/mSin3A complex from the promoter. PMID: 18372343
32. These data demonstrate that targeted degradation of NFX1-91 by E6/E6AP dissociates the mSin3A/HDAC complex from the hTERT promoter and induces hTERT transcription. PMID: 18505829
33. Resullts show that SHP and Sin3A play an important role in adamantyl-substituted retinoid-related induction of cellular apoptosis. PMID: 19509248
34. These data support a model of repression wherein actions of ERalpha and Sin3A at the proximal promoter can overcome activating signals at distal or proximal sites and ultimately decrease gene expression. PMID: 19620290
35. The transcriptional repressor mSin3A associates with histone deacetylase 1 forming a co-repressor complex. See also PMID (PubMed identifier) 9150133. PMID: 9150134
36. mSin3A interacts with HDAC2 via the HDAC-interacting domain (HID) of mSin3A. PMID: 9150134

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HGNC: 19353

OMIM: 607776

KEGG: hsa:25942

STRING: 9606.ENSP00000353622

UniGene: Hs.513039