Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity).
The following SIN3A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SIN3A Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA021327GA01HU | SIN3A Antibody | Human,Mouse,Rat | ELISA,WB,IF |
CSB-PA836303LA01HU | SIN3A Antibody | Human | ELISA, WB, IHC |
CSB-RA242724A0HU | SIN3A Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IF |
SIN3A Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP730630MO CSB-EP730630MO CSB-BP730630MO CSB-MP730630MO CSB-EP730630MO-B |
Recombinant Mouse Paired amphipathic helix protein Sin3a (Sin3a), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SIN3A Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP836303HU CSB-EP836303HU CSB-BP836303HU CSB-MP836303HU CSB-EP836303HU-B |
Recombinant Human Paired amphipathic helix protein Sin3a (SIN3A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |