Product Details

Uniprot No.

Target Names

SLC27A4

Alternative Names

Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (EC 6.2.1.-) (Solute carrier family 27 member 4), SLC27A4, ACSVL4 FATP4

Species Reactivity

Human, Mouse

Immunogen

A synthesized peptide derived from human SLC27A4

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

Rabbit IgG

Clone No.

11A1

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The SLC27A4 monoclonal antibody was produced using thesynthesized peptide derived from human SLC27A4 protein as the immunogen. The cDNA was sequenced to obtain the DNA sequence of the SLC27A4 monoclonal antibody, and the gene was then cloned into a plasmid vector. The plasmid vector was transfected into the host cell using a suitable method. The resulting SLC27A4 recombinant monoclonal antibody was purified using affinity chromatography, and its specificity was tested in ELISA and WB. It can detect human and mouse SLC27A4 proteins.

The SLC27A4 protein, also known as FATP4, mainly transports long-chain fatty acids into cells. It is primarily expressed in the liver and small intestine. It plays a crucial role in lipid metabolism and homeostasis, as well as energy production. Mutations in the SLC27A4 gene have been linked to several metabolic disorders, including ichthyosis prematurity syndrome, a rare genetic disorder characterized by dry, scaly skin and respiratory problems.

Target Background

Function

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Probably involved in fatty acid transport across the blood barrier. Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones.

Gene References into Functions

SLC27A4 gene mutation is responsible in the diagnosis of ichthyosis prematurity syndrome in a premature infant. PMID: 26341232
expand the mutational repertory of FATP4 with three undescribed pathogenic mutations in two families PMID: 27168232
The results have interesting implications that SLC27A4/ATG4B complex might be conducive to the occurrence of autophagy in human cancer cells, which is meaningful investigations toward the aim of developing autophagy-targeting drugs and have significant values in clinical application. PMID: 26662804
no association between placental expression and maternal body mass index PMID: 27016784
we resequenced the SLC27A3 and SLC27A4 genes using 267 autism spectrum disorders(ASD) patient and 1140 control samples and detected 47 and 30 variants for the SLC27A3 and SLC27A4, revealing that they are highly polymorphic with multiple rare variants. PMID: 26548558
We describe two siblings with ichthyosis prematurity syndrome and report a recurrent homozygous mutation (c.1430T>A) that is predicted to lead to a p.Val477Asp substitution in fatty acid transport protein 4. PMID: 24889544
the cell surface protein CD36/FAT directly facilitates fatty acid transport across the plasma membrane, whereas the intracellular acyl-CoA synthetases FATP4 and ACSL1 enhance fatty acid uptake indirectly by metabolic trapping PMID: 24503477
the clinical implications of defects in these transporters and relevant animal models, including the FATP4 animal models and ichthyosis prematurity syndrome, a congenital ichthyosis caused by FATP4 deficiency. [review] PMID: 24120574
FATP4, ichthyin and TGM1 interact in lipid processing essential for maintaining the epidermal barrier function PMID: 23290633
FATP4 plays crucial roles in the development and maturation of both sebaceous and meibomian glands, as well as in the formation and composition of sebum PMID: 23271751
FATP1 and FATP4 proteins perform different functional roles in handling long chain fatty acids in skeletal muscle PMID: 22235293
even though hypoxia regulates the expression of FATP2 and FATP4 in human trophoblasts, mouse Fatp2 and Fatp4 are not essential for intrauterine fetal growth. PMID: 22028793
Mutation in FATP4 in a patient with self-healing congenital verruciform hyperkeratosis.( PMID: 20815031
findings propose fatty acid transport protein 4 as a candidate gene for the insulin resistance syndrome PMID: 14715877
intra-pair correlations revealed that FATP4 expression was significantly up-regulated in acquired obesity." PMID: 15168018
Data suggest that endogenous FATP4 does not function to translocate fatty acids across the plasma membrane, but functions more as a very long-chain acyl-CoA synthetase. PMID: 17901542
Mutations in FATP4 gene cause the ichthyosis prematurity syndrome. PMID: 19631310

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Involvement in disease

Ichthyosis prematurity syndrome (IPS)

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein Families

ATP-dependent AMP-binding enzyme family

Tissue Specificity

Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tiss

Database Links

HGNC: 10998

OMIM: 604194

KEGG: hsa:10999

STRING: 9606.ENSP00000300456

UniGene: Hs.656699

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Code	CSB-RA235828A0HU
Size	US$210
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Image	Western Blot Positive WB detected in: MCF-7 whole cell lysate, Mouse brain tissue All lanes: SLC27A4 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 73, 27 kDa Observed band size: 42 kDa
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SLC27A4 Recombinant Monoclonal Antibody

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Target Background