USP11 Recombinant Monoclonal Antibody

1. FASN-induced S6 kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in diffuse large B-cell lymphoma. PMID: 29483509
2. These findings reveal an important mechanism by which p21 can be stabilized by direct deubiquitylation, and they pinpoint a crucial role of the USP11-p21 axis in regulating cell-cycle progression and DNA damage responses. PMID: 29666278
3. show that USP11 is associated with the mitotic spindle, does not regulate SAC inactivation, but controls ubiquitination of RAE1 at the mitotic spindle, hereby functionally modulating its interaction with Nuclear Mitotic Apparatus protein (NuMA) PMID: 29293652
4. High USP11 expression is associated with cancer. PMID: 26919101
5. USP11 may contribute to the pathogenesis of pulmonary fibrosis by stabilization of TbetaRII and promotion of TGFbeta-1 signaling. PMID: 27853171
6. We demonstrated that, while depletion of XIAP attenuates cell transformation, elevated USP11 significantly promotes the tumor colony formation through stabilization of XIAP. PMID: 28040451
7. These findings elucidate deeply and extensively the mechanism of RNF8/RNF168 and USP11 to maintain the proper status of ubiquitylation gammaH2AX to repair double strand breaks. PMID: 26507658
8. novel insight into cross-talk between ubiquitin and SUMO and uncover USP11 and RNF4 as a balanced SUMO-targeted ubiquitin ligase/protease pair with a role in the DDR. PMID: 25969536
9. PML degradation mechanism through Notch/Hey1-induced repression of USP11 involved in brain tumour pathogenesis PMID: 24487962
10. USP11 is a novel regulator of p53, which is required for p53 activation in response to DNA damage PMID: 25471832
11. Our data support a model whereby USP11 domains outside the catalytic core domain serve as protein interaction or trafficking modules rather than a direct regulatory function of the proteolytic activity. PMID: 24724799
12. USP-11 is not a predictor of a pCR after anthracycline-taxane-containing NST for breast cancer. Low USP-11 expression was independently correlated with better survival outcomes. PMID: 23337751
13. USP11 augments TGFbeta signalling by deubiquitylating ALK5. PMID: 22773947
14. Ubiquitin specific protease 11 protein plays an important role in maintaining a delicate balance in TNFalpha-mediated inflammatory responses by being a part of Yin-Yang regulatory mechanism. PMID: 19874889
15. structural and functional characterization of the USP11 deubiquitinating enzyme PMID: 12084015
16. Results suggest that BRCA2 expression levels are regulated by ubiquitination in response to DNA damage and that USP11 participates in DNA damage repair functions within the BRCA2 pathway independently of BRCA2 deubiquitination. PMID: 15314155
17. the ectopic expression of IKKalpha into cells silenced for USP11 restores p53 expression, demonstrating that USP11 functions as an upstream regulator of an IKKalpha-p53 signaling pathway. PMID: 17897950
18. USP11 plays an important role in regulating the levels of E7 protein and subsequently affects the biological function of E7 as well as its contribution to cell transformation by HPV-16E7. PMID: 18408009

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HGNC: 12609

OMIM: 300050

KEGG: hsa:8237

STRING: 9606.ENSP00000218348

UniGene: Hs.171501