YBX1 Recombinant Monoclonal Antibody

1. The study establishes YBX1 as a posttranscriptional effector required for maintenance of epidermal homeostasis. PMID: 29712925
2. Phosphorylation of nuclear YB-1 after stimulation with epidermal growth factor is associated with nuclear accumulation of p90 ribosomal S6 kinase but not of YB-1. PMID: 30126195
3. this study identifies a novel lncRNA termed lncRNA-AWPPH which is highly expressed in hepatocellular carcinoma (HCC), indicates poor prognosis of HCC patients, and promotes HCC cell proliferation, migration, and in vivo tumor growth and metastasis via a novel regulatory mechanism of interacting with YBX1. PMID: 28428004
4. YB-1 regulates miR-155 expression via c-Myb in the laryngeal squamous cell carcinoma.Laryngeal squamous cell carcinoma patients with high YB-1 expression showed poor overall survival. PMID: 29517281
5. infiltrating CD4 + T cells promoted TGFbeta1 expression in both renal cell carcinoma and T cells and regulated renal cell carcinoma cells proliferation via modulating TGFbeta1/YBX1/ HIF2alpha signals PMID: 29289594
6. structural basis of the interactions between YB-1 and mRNAs carrying the aforementioned motifs PMID: 29133115
7. YB-1 silencing sensitized SH-SY5Y cells to cisplatin and promoted the apoptosis induced by cisplatin due to down-regulation of multidrug resistance (MDR) 1 protein via NF-kappaB signaling pathway. PMID: 28382490
8. These results suggest that extracellular vesicles and exosomes could play a role in the purging and intercellular transfer of excess free RNAs, including full-length transfer RNAs and other small noncoding RNAs. PMID: 29073095
9. YB-1 promoted lung adenocarcinoma growth and progression in vitro and in vivo through directly binding to the MACC1 promoter and enhancing MACC1/c-Met pathway. PMID: 28624808
10. Data indicate that YB-1 translocates to the nucleus coordinately with p53 expression and is involved in gemcitabine resistance in bladder cancer suggesting that nuclear expression of YB-1 is important for resistance to chemotherapy including gemcitabine in TP53-mutated bladder cancer. PMID: 28714514
11. Results show that YBX1 expression is regulated by TP53TG1 which binds to YBX1 promoter and prevents its nuclear localization. PMID: 27821766
12. Kindlin-2 is up-regulated in glioma cells and acts as an oncogene. It is an independent risk factor for poor prognosis. The Kindlin-2/YB-1/beta-catenin complex promotes EGFR transcription and contributes to glioma progression. Kindlin-2 is a potential diagnostic and prognostic marker in glioma, and inhibition of Kindlin-2 may be a novel strategy for glioma treatment. PMID: 27713156
13. Results showed that YB-1 promoted hepatocellular carcinoma (HCC) cell proliferation, migration and colony formation. Also, YB-1 was found to increased drug resistance in HCC. These findings suggested that YB-1 was a key factor in HCC tumorigenesis and maintained the HCC initiating cell population. PMID: 27911878
14. Furthermore, use of both indirubin 3'-oxime and actinomycin D in combination increased the anticancer effect on HepG2 cells. Indirubin 3'-oxime is a novel and efficient inhibitor of anticancer agent-induced YB-1 nuclear translocation. PMID: 29274785
15. It would appear that YB-1 could regulate cell invasion and migration via downregulation of its indirect target coronin-1C. The association between YB-1 and coronin-1C offers a novel approach by which metastasis of breast cancer cells could be targeted and abrogated. PMID: 28302118
16. Inhibition of YBX1 suppressed lung cancer growth partly via the CDC25a pathway and high expression of YBX1/CDC25a predicts poor prognosis in human lung adenocarcinoma. PMID: 27384875
17. The long noncoding RNA CAR intergenic 10 bound and stabilized transcription factor Y-box-binding protein 1 (YB-1), leading to up-regulation of the epidermal growth factor receptor (EGFR) and proliferation of lung cancer cells. PMID: 27322209
18. Results firstly reported that YB-1 whose mRNA expression is regulated by HPV18 E6 promotes epithelial-mesenchymal transition and progression of cervical cancer via enhancing the expressions of Snail. PMID: 28708785
19. YB-1 localization was significantly altered in the nuclei of tumor blasts derived from bone marrow or peripheral blood. PMID: 28009354
20. Two interacting partners of urokinase-type plasminogen activator (uPA) receptor, the cysteine-rich angiogenic inducer 61 (Cyr61) and the Y-box-binding protein 1 (YB-1) were identified and their differential expression demonstrated in the triple-negative breast cancer (TNBC) cells as well as in tumors. PMID: 27286449
21. No other significant associations between clinical prognostic factors and YB-1/p18 serum levels were detected. PMID: 27371774
22. Data suggest that oncogenic Y-box binding protein 1 (YB-1) indirectly enhances transforming growth factor beta (TGFbeta) signaling cascades via Sma/Mad related protein 2 (Smad2)phospho-activation and may represent a promising factor for future diagnosis and therapy of breast cancer. PMID: 29187452
23. High YBX1 expression is associated with invasion in nasopharyngeal carcinoma. PMID: 29024700
24. TCTP interacted with Y-box-binding protein 1 (YBX1), and their interaction was localized to the N-terminal region of TCTP and the 1-129 amino acid (aa) residues of YBX1. The interaction of TCTP with YBX1 might cooperate or coordinate their functions in the control of diverse regulatory pathways in cancer cells. PMID: 27607350
25. YB-1 expression promotes pancreatic cancer metastasis that is inhibited by microRNA-216a. PMID: 28782557
26. findings point to YB-1 and NSUN2 as possible mediators of the process of transfer of specific mRNAs into exosomes, allowing us to speculate on an involvement of these proteins in the mRNA sorting via the recognition of the above motifs PMID: 28341602
27. YB-1 is induced by Shh in CGNPs PMID: 26725322
28. FOXO3a nuclear expression was inversely correlated with YB-1 nuclear expression in prostate cancer tissues. PMID: 27699813
29. these findings define a mechanism of drug resistance through which YBX1 contributes to antiestrogen bypass in breast cancer cells PMID: 27879270
30. High YB1 expression is associated with Cisplatin Resistance in Gastric Cancer. PMID: 27013200
31. Collectively, these findings demonstrate a novel role of YBX1 in maintaining the stemness of CSCs and metastasis, unveiling YBX1 as promising therapeutic target for NSCLC treatments. PMID: 28400280
32. These studies reveal the functional role of YB-1 in the Angiogenin-mediated stress response program. PMID: 27174937
33. Together, these results indicate that transportin-1 mediates YB-1 nuclear translocation. PMID: 27794479
34. YB-1 is a novel binding factor for hypoxia-responsive elements that participates in fine-tuning of the hypoxia transcriptome. PMID: 27524241
35. The long noncoding RNA highly up-regulated in liver cancer (HULC) promotes the phosphorylation of YB-1 through the extracellular signal-regulated kinase pathway, in turn regulates the interaction of YB-1 with certain oncogenic mRNAs, and consequently accelerates the translation of these mRNAs in the process of tumorigenesis. PMID: 28027578
36. glycosylated-YB-1 mainly enhanced cell proliferation through congenerous actions with YB-1 phosphorylation and thus played indispensable roles in fine-tuning cell proliferation PMID: 27751836
37. Silencing of YB-1 could sensitize DLBCL cells to mitoxantrone and overcome cell adhesion-mediated drug resistance (CAM-DR) phenotype in an AKT-dependent manner. PMID: 27397581
38. these data suggest that C1QBP could regulate YBX1 to suppress the AR-enhanced RCC cell invasion. Targeting this newly identified C1QBP/YBX1/AR/MMP9 signal pathway may provide a new potential therapy to better suppress RCC metastasis. PMID: 28107702
39. Tumor growth and liver metastasis formation were significantly suppressed in nude mice after implantation of YB-1-silenced PDAC cells, and the YB-1 targeting antisense oligonucleotide significantly inhibited the growth of subcutaneous tumors. PMID: 26939718
40. we propose a model whereby high YB-1 levels in some TNBC cells can lead to reduced levels of EGR1, which in turn promotes slow cell cycling and resistance to PTX. Therefore YB-1 and EGR1 levels are biologically linked and may provide a biomarker for TNBC response to PTX. PMID: 27072400
41. LL37 induced YB1 expression, and increased tumor cell proliferation, migration and invasion of A375 and A875 malignant melanoma cell lines. PMID: 27922666
42. Down-regulation of miR-137 conferred OXA resistance in parental cells, while over-expression of miR-137 sensitized resistant cells to OXA, which was partly rescued by YBX1 siRNA. PMID: 28035913
43. suggests that selective inhibition of translation of YB-1 mRNA, and probably some other mRNAs as well, by mTOR kinase inhibitors is not mediated by the action of the 4E-binding protein upon functions of the 4F-group translation initiation factors PMID: 26931209
44. Cytoplasmic expression of YB-1 was associated with more aggressive tumor and poor overall survival in breast cancer. PMID: 26193840
45. High-grade nuclear YB-1 expression was detected in 62.9% of colorectal cancer cases and was found to be an independent predictor of poorer overall survival and relapse-free survival. PMID: 27354655
46. Study shows that DeltaNp63alpha controls YB-1 protein stability suggesting that DeltaNp63alpha/YB-1 cross talk is relevant for survival of basal keratinocytes in stratified epithelia. PMID: 27168020
47. These findings demonstrate the oncogenic roles of YB-1 in esophageal squamous cell carcinoma (ESCC) and support it as a target for ESCC therapy. PMID: 27044807
48. Immunofluorescence staining was used to detect the levels of YB-1 in the cytoplasm and the nucleus, and results indicated that the intracellular distribution was significantly associated with the pathological grade of glioma PMID: 26936129
49. Results show that high GOLPH3 and nuclear/cytoplasmic YB-1 expression correlated with a poor prognosis in patients with prostate cancer. PMID: 26794392
50. Data suggest that poly(ADP-ribosyl)ation of YB-1 (multifunctional Y-box binding protein 1) is catalyzed by PARP1 [poly(ADP-ribose)polymerase 1] and can be up-regulated by damaged DNA. PMID: 26453809

Show More

Hide All

HGNC: 8014

OMIM: 154030

KEGG: hsa:4904

STRING: 9606.ENSP00000361626

UniGene: Hs.473583