Recombinant Chicken CD166 antigen (ALCAM)

Code CSB-CF001562CH
MSDS
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names
Uniprot No.
Alternative Names
ALCAM; CD166 antigen; Activated leukocyte cell adhesion molecule; BEN glycoprotein; Protein DM-GRASP; Protein JC7; SC1 glycoprotein; CD antigen CD166
Species
Gallus gallus (Chicken)
Expression Region
34-588
Target Protein Sequence
LYTVNAVYGDTITMPCRLEVPDGLMFGKWKYEMPNGSPVFIAFRSSTKKNVQYDDVPDYKDRLSLSENYTLSIKNARISDEKRFVCMLVTEDDVSEEPTVVKVFKQPSQPEILHQADFLETEKLKMLGECVVRDSYPEGNVTWYKNGRVLQPVEEVVVINLRKVENRSTGLFTMTSSLQYMPTKEDANAKFTCIVTYHGPSGQKTIQSEPVVFDVHYPTEKVTIRVLSQSSTIKEGDNVTLKCSGNGNPPPQEFLFYIPGETEGIRSSDTYVMTDVRRNATGEYKCSLIDKSMMDATTITVHYLDLQLTPSGEVTKQIGEALPVSCTISSSRNATVFWIKDNTRMKTSPSFSSLQYQDAGNYICETTLQEVEGLKKRKTLKLIVEGKPQIKMTKKTNTNKMSKTIVCHVEGFPKPAVQWTVTGSGSLINKTEETKYVNGKFSSKIIIAPEENVTLTCIAENELERTVTSLNVSAISIPEYDEPEDRNDDNSEKVNDQAKLIVGIVVGLLLVALVAGVVYWLYVKKSKTASKHVDKDLGNIEENKKLEENNHKSET
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6. Contributes to the formation and maturation of the immunological synapse via its interactions with CD6. Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation. Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons.
Gene References into Functions
  1. impact of the growth cone translation of ALCAM on axonal functions PMID: 22421359
  2. SC1 might play a potential role in both the structural formation of nephroblastomas, based on its adhesive activity, and normal renal development. PMID: 16328046
  3. ubiquitination and endocytosis of DM-GRASP in concert regulate its cell surface concentration, which is crucial for its function in axon navigation PMID: 18790729
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.
Tissue Specificity
Detected in embryo. Detected in embryonic spinal cord and embryonic brain. Within the spinal cord it is localized to axons in the dorsal funiculus, midline floor plate cells, and motoneurons. Detected in embryonic epithelia and brain. After hatching, dete
Database Links
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