Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2(SRD5A2)

Code CSB-CF022654HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P31213
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
Source in vitro E.coli expression system
Gene Names SRD5A2
Protein Names Recommended name: 3-oxo-5-alpha-steroid 4-dehydrogenase 2 EC= 1.3.99.5Alternative name(s): 5 alpha-SR2 SR type 2 Steroid 5-alpha-reductase 2 Short name= S5AR 2 Type II 5-alpha reductase
Expression Region 1-254
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Involvement in disease Pseudovaginal perineoscrotal hypospadias (PPSH)
Subcellular Location Microsome membrane, Multi-pass membrane protein, Endoplasmic reticulum membrane, Multi-pass membrane protein
Protein Families Steroid 5-alpha reductase family
Tissue Specificity Expressed in high levels in the prostate and many other androgen-sensitive tissues.
Database Links

HGNC: 11285

OMIM: 264600

KEGG: hsa:6716

UniGene: Hs.458345

Q&A and Customer Reviews

Q&A
Q:

Regarding your protein CSB-CF022654HU, could you please advise on the lead time, the sequencing, the pricing, and the expected tag information?
Also, how long after the expression begins would you know what kind of tag this protein is ultimately going to have?
Lastly, what is the expected purity?

A:
Very nice to receive your inquiry.
Expression Region: 1-254 aa; Full length.
Tag information:Tag type will be determined during the manufacturing process. (The expected tag is N-terminal 10xHis-tagged)
Sequence:

MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF


The expected tag of CSB-CF022654HU is N-terminal 10xHis-tagged, if you have any special requirement for the tag, you can communicate with us in advance.
Generally, the tag of this protein can be confirmed in 15-20 working days after we receive your order.
Regarding the purity, the minimum purity that we can guarantee is 85%, which means that the purity of final protein will be above 85%.
If the customer requires much higher purity than 85%, pls remark this requirement in the order, we can try our best, but as we have never expressed, so we can't guarantee it can reach 90% or 95%.
Partial protein to recommend:
Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2(SRD5A2),partial
CSB-YP022654HU1 >> Yeast
CSB-EP022654HU1 >> E.coli
CSB-BP022654HU1 >> Baculovirus
CSB-MP022654HU1 >> Mammalian cell
Expression Region: 29-71aa; Partial.
Tag information:EP, YP, BP, MP: Tag type will be determined during the manufacturing process.
The expected tag for each expression system is list as follows:
YP, BP, MP: N-terminal 6xHis-tagged; EP: N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged.
Sequence:

KPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQ

Customer Reviews

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