Recombinant Human Amyloid-like protein 1(APLP1)

Code CSB-CF001911HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P51693
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence SLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP
Source in vitro E.coli expression system
Gene Names APLP1
Protein Names Recommended name: Amyloid-like protein 1 Short name= APLP Short name= APLP-1 Cleaved into the following chain: 1. C30
Expression Region 39-650
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
Subcellular Location Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: C30: Cytoplasm
Protein Families APP family
Tissue Specificity Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD).
Database Links

HGNC: 597

OMIM: 104775

KEGG: hsa:333

STRING: 9606.ENSP00000221891

UniGene: Hs.74565

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