Recombinant Human Aquaporin-2(AQP2)

Code CSB-CF001962HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P41181
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA
Source in vitro E.coli expression system
Gene Names AQP2
Protein Names Recommended name: Aquaporin-2 Short name= AQP-2Alternative name(s): ADH water channel Aquaporin-CD Short name= AQP-CD Collecting duct water channel protein WCH-CD Water channel protein for renal collecting duct
Expression Region 1-271
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Involvement in disease Diabetes insipidus, nephrogenic, autosomal (ANDI)
Subcellular Location Apical cell membrane, Multi-pass membrane protein, Basolateral cell membrane, Multi-pass membrane protein, Cytoplasmic vesicle membrane, Multi-pass membrane protein, Golgi apparatus, trans-Golgi network membrane, Multi-pass membrane protein
Protein Families MIP/aquaporin (TC 1.A.8) family
Tissue Specificity Expressed in renal collecting tubules.
Database Links

HGNC: 634

OMIM: 107777

KEGG: hsa:359

STRING: 9606.ENSP00000199280

UniGene: Hs.130730

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