Recombinant Human Bcl-2-interacting killer (BIK)

1. the results revealed the autophagy modulator TMEM74 interrelates with apoptosis inducer BIK and inhibits its function. PMID: 28412412
2. Data suggest that the ERalpha-H19-BIK signaling axis plays an important role in promoting breast cancer cell chemoresistance. PMID: 27845892
3. Suggest complex mechanism of tumor promotion in Bik high breast tumors. PMID: 27120789
4. BIK significantly contributes to DNA damage-induced mitochondrial apoptosis in HCT-116 wt cells upstream of the second peak of ROS production, BAX and BAK activation, cytochrome c release and caspase activation. PMID: 28796811
5. These studies suggest a link between Bik-mediated caspase activation and cleavage of viral proteins. PMID: 26437021
6. our data demonstrated that suppression of BIK in ER-positive MCF-7 cells prevents the cytotoxic effect of TAM and favors a more aggressive phenotype, due to the molecular change of different pathways PMID: 25861752
7. HCV RNA replication and release were significantly suppressed in BIK-depleted cells and over-expression of the RNA-dependent RNA polymerase, NS5B, was able to induce BIK expression PMID: 25463603
8. BikDDA, a novel mutant of Bik, showed a prolonged half-life and enhanced pro-apoptotic ability in triple-negative breast cancer cells compared with BikDD. PMID: 24637719
9. Findings identify novel cross talk between autophagy and apoptosis, wherein targeting SQSTM1/p62 converts cytoprotective autophagy to an inefficient form due to cargo loading failure, leading to NBK/Bik accumulation, which triggers apoptosis. PMID: 25002530
10. Authors show that human herpesvirus 4 EBNA2 represses BIK in B-cell lymphoma-derived cell lines and that this host-virus interaction can inhibit the proapoptotic effect of transforming growth factor beta1. PMID: 24554662
11. Data suggest BIK expression in tumor cells is not subject to direct regulation by MAP kinase signaling; BIK expression appears to be cell-cycle-dependent and increases in G1 cell-cycle arrest which results from inhibition of MAP kinase signaling. PMID: 24527759
12. BIK/NBK gene expression may have important clinical implications and provide predictive, prognostic or therapeutic marker in breast cancer patients PMID: 22855140
13. Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik. PMID: 22388352
14. A previously undescribed indirect epigenetic regulation of BIK in FA-C lymphoblasts is mediated by DeltaNp73, an isoform of p73 lacking its transactivation domain that activates BIK through a proximal element in its promoter. PMID: 22873408
15. Data indicate that methylation-induced transcriptional silencing of the BIK (bcl2-interacting killer) pro-apoptotic gene may occur in multiple myeloma (MM), which might serve as a predictor of the development of relapsed/refractory MM. PMID: 22288719
16. Data show that association of study-wide significance (P < 8.2 x 10(-5)) was identified for single-nucleotide polymorphisms (SNP) in TP53, LIG1, and BIK. PMID: 22139380
17. Bik has a role in both, apoptosis induction and sensitivity to oxidative stress in myeloma cells. PMID: 21063407
18. Systemic tumor suppression by the proapoptotic gene bik. PMID: 11782349
19. The results identify BIK as an initiator of cytochrome c release from mitochondria operating from a location at the ER. PMID: 11884414
20. NBK mediates apoptosis entirely by BAX-dependent mitochondrial pathway. PMID: 12853473
21. Several sequence alterations of the BIK gene have been identified in peripheral B-cell lymphomas which may have a role in disease pathogenesis. PMID: 12874789
22. Bik is induced in MCF-7 cells in the absence of estrogen signaling and plays a critical role in the antiestrogen-provoked breast cancer cell apoptosis. PMID: 14983013
23. degraded in Chlamydia trachomatis-infected cells. PMID: 15731089
24. Bik and Bim have roles in bortezomib sensitization of cells to killing by death receptor ligand TRAIL PMID: 15767553
25. Data show that BIK activates recruitment of DRP1 to the surface of the endoplasmic reticulum in intact cells, resulting in mitochondrial fragmentation but little release of cytochrome c to the cytosol. PMID: 15791210
26. Endogenous cellular BIK, therefore, regulates a BAX,BAK-dependent ER pathway that contributes to mitochondrial apoptosis PMID: 15809295
27. Bik/NBK accumulation was caused by stabilization of the protein from degradation and was associated with bortezomib cytotoxicity and apoptosis induction. PMID: 15824729
28. Bik does not have a definitive role in development and progression of sporadic breast neoplasms in Mexican females PMID: 16060964
29. E2Fs transactivate bik by a p53-independent mechanism. PMID: 17027756
30. Results suggest that expression of BIK in human breast cancer cells is regulated at the mRNA level by a mechanism involving a nontranscriptional activity of p53 and by proteasomal degradation of BIK protein. PMID: 17047080
31. The activation of caspase-9 and depolarization of mitochondrial membrane potential were induced by BIK, which were decreased concomitant with caspase-12 silenced. PMID: 17574210
32. Genes encoding KU70, MGST1 and BIK show age-related mRNA expression levels in hematopoietic stem cells. PMID: 17714764
33. The depletion of ER Ca2+ stores rather than the elevation of cytosolic Ca2+ or the extracellular Ca2+ entry contributed to Bik-induced Hep3B cells apoptosis. PMID: 18299962
34. BIK might not play a major role in the susceptibility of schizophrenia in Japanese population. PMID: 19632297
35. BIK is mainly localized in the ER & induces apoptosis through the mitochondrial pathway. It is involved in mature B cell selection. It a pro-apoptotic tumor suppressor in several human tissues. Review. PMID: 19641504
36. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18519826

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HGNC: 1051

OMIM: 603392

KEGG: hsa:638

STRING: 9606.ENSP00000216115

UniGene: Hs.475055