Recombinant Human C5a anaphylatoxin chemotactic receptor 2(C5AR2)-VLPs

1. Both rs2972607 and rs8112962 SNPs of C5L2 are associated with coronary artery disease in a Han population of China. PMID: 28052000
2. Studies indicate that the complement response lie the active fragments, C3a and C5a, acting through their specific receptors, C3aR, C5aR1 and C5aR2 to direct the cellular response to inflammation. PMID: 28576324
3. negative regulator of BDNF secretion by pulp fibroblasts under carious teeth PMID: 28033061
4. All the C698T genotypes and allele frequencies in C5L2 were almost similar in both the cases and controls. PMID: 25935173
5. C5AR and C5L2-mediated neutrophil dysfunction is associated with a poor outcome in sepsis. PMID: 25726869
6. this study reveals a novel role for C5aR2 in C5a-mediated activation of mast cells and demonstrates that C5aR2 ligation initiates a beta-arrestin-2-, PI3K-, and ERK-dependent signaling pathway in these cells. PMID: 26283482
7. C5a2 can modulate ERK1/2 signaling in macrophages via heteromer formation with C5a1 and beta-arrestin recruitment. PMID: 24777312
8. prominent C5L2 expression in advanced atherosclerotic stages directly correlates with high levels of proinflammatory cytokines PMID: 24819959
9. The present study has extended the mutation spectrum of C5L2, and Thr196Asn mutations in C5L2 were associated with retinitis pigmentosa and serum lipid levels. PMID: 24885523
10. C5aR and C5L2 may have roles in adiposity in women PMID: 24523571
11. A novel polymorphism (901G > a) of C5L2 gene is associated with coronary artery disease in Chinese Han and Uyghur population. PMID: 24073849
12. our study indicates that 698C>T polymorphism of C5L2 gene is associated with the T2DM in individuals of Saudi population which was found to be similar with other studies. PMID: 24078164
13. C5L2 may be implicated in the pro-inflammatory role in C5a-primed neutrophils for ANCA-induced activation. PMID: 23785491
14. C5L2 receptors are abundant in neurofibrillary tangles in Alzheimer's disease brain compared to controls. PMID: 23394121
15. The results suggest that insulin sensitivity may be permissive for coupling of C5L2 levels to lipid storage and utilization. PMID: 23460866
16. C5L2 has been recently demonstrated to physically interact with both C5aR and beta-arrestin to negatively regulate C5aR signaling toward an anti-inflammatory manner PMID: 23239822
17. C5L2 was expressed in the kidney and localized to the distal convoluted tubule and connecting tubule. PMID: 22960554
18. genetic association studies in the Chinese Han population: Data suggest that an SNP in C5L2 (C698T) is associated with type 2 diabetes mellitus; 698CT heterozygotes exhibited increased serum triglyceride levels. PMID: 22180093
19. The aim of this study was to investigate the genetic alterations and mRNA expression pattern of C5aR and C5L2 genes in neutrophils from attack-free familial Mediterranean fever patients. PMID: 22187344
20. Neither the familial combined hyperlipidemia subjects nor the type 2 diabetes patients were found to have the S323I variant of the C5L2 gene. PMID: 22194190
21. negatively modulated during TLR-mediated enhancement of C5a-induced proinflammatory responses PMID: 21630250
22. 698CT genotype of C5L2 may be a genetic maker of CAD in the Han and Uygur population in western China PMID: 21698200
23. Data show that C5L2 is predominantly intracellular, while C5aR is expressed on the plasma membrane, and that internalized C5aR following ligand binding is co-localized with both C5L2 and beta-arrestin. PMID: 20044484
24. These results suggest that C5L2 is an anaphylatoxin-binding protein with unique ligand binding and signaling properties. PMID: 11773063
25. A8Delta71-73 is the first antagonist of c5a that blocks C5a and C5adesArg74 binding to C5L2 making it a valuable tool for studying C5L2 functions. PMID: 14570896
26. C5L2 on neutrophils diminishes during sepsis due to systemic generation of complement 5a (C5a), which is associated with a poor prognosis. PMID: 15634936
27. first demonstration that C5L2 is a functional receptor, mediating acylation-stimulating protein triglyceride stimulation PMID: 15833747
28. C5L2 is a highly regulated scavenger receptor for C5a and C5a-des-Arg(74) PMID: 17068344
29. C5L2 appears to bind complement factor C5a and C5a des Arg by different mechanisms, and, unlike C5a receptor (C5aR), C5L2 uses critical residues in its N-terminal domain for binding only to C5a des Arg. PMID: 17158873
30. a major function of human C5L2 is to remove active complement fragments from the extracellular environment. PMID: 19100624
31. C5L2 is a functional metabolic receptor, and serine 323 is important for ASP induced functionality. PMID: 19615750
32. Recombinant C3adesArg/acylation stimulating protein (ASP) is highly bioactive: a critical evaluation of C5L2 binding and 3T3-L1 adipocyte activation. PMID: 19767107
33. C3a des Arg77 binds to C5L2 but not to the C3a receptor (LocusID: 719). C3a and C3a des Arg77 both stimulate triglyceride synthesis (acylation stimulating protein, ASP) in adipocytes and fibroblasts and so C5L2 could be the receptor for ASP. PMID: 12540846
34. C5L2 is a high affinity binding protein for C5a and C5a des Arg74, and has a moderate affinity for C3a. Unlike the original receptors for C5a (CD88) and C3a (C3aR), C5L2 couples weakly to Gi-mediated signalling pathways. PMID: 11773063

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HGNC: 4527

OMIM: 609949

KEGG: hsa:27202

STRING: 9606.ENSP00000257267

UniGene: Hs.534412