Recombinant Human Membrane-spanning 4-domains subfamily A member 4A (MS4A4A)

Code CSB-CF822238HU
MSDS
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names
MS4A4A
Uniprot No.
Alternative Names
MS4A4A; 4SPAN1; CD20L1; MS4A4; HDCME31P; Membrane-spanning 4-domains subfamily A member 4A; CD20 antigen-like 1; Four-span transmembrane protein 1
Species
Homo sapiens (Human)
Expression Region
1-239
Target Protein Sequence
MHQTYSRHCRPEESTFSAAMTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLK GEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIA AGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSI LMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
May be involved in signal transduction as a component of a multimeric receptor complex.
Gene References into Functions
  1. MS4A4A is expressed at the plasma membrane in monocytes but not in granulocytes or lymphocytes. PMID: 28303902
  2. MS4A4A expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
  3. MS4A4 in human mast cells effects ligand-induced KIT endocytosis pathways and reduced receptor recycling to the cell surface, thus promoting KIT signaling in the endosomes while reducing that in the plasma membrane. PMID: 25717186
  4. Single nucleotide polymorphisms in APOE-epsilon4, CLU and MS4A4A influence both Alzheimer disease risk and cerebrospinal fluid Amyloid-beta1-42 levels. PMID: 23573206
Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
MS4A family
Tissue Specificity
Variable expression in multiple hemopoietic cell lines.
Database Links

HGNC: 13371

OMIM: 606547

KEGG: hsa:51338

STRING: 9606.ENSP00000338648

UniGene: Hs.325960

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