Recombinant Human P2Y purinoceptor 2 (P2RY2)

1. Study demonstrated that the P2Y2 receptor was highly expressed in MCF7 and Hs578T breast cancer cells and indicated that the P2Y2 receptor promoted cell migration and invasion in breast cancer cells via EMT-related genes Snail and E-cadherin. PMID: 29115551
2. Our results clearly demonstrate the involvement of P2Y2R subtypes in the pathogenesis of fibrotic lung diseases in humans and mice and hence support the development of selective P2Y2R antagonists for the treatment of IPF. PMID: 28415591
3. Proliferation and migration of functionally impaired cardiac progenitor cells are enhanced by P2Y2R-mediated YAP activation, revealing a novel link between extracellular nucleotides released during injury/stress and Hippo signaling-a central regulator of cardiac regeneration. PMID: 28923792
4. nterleukin-8 release after purinergic stimulation in ALI-cultured HEECs is mediated through P2Y2 receptor activation. PMID: 27977904
5. Human umbilical vein endothelial cells exposed to either P2Y2 receptor antagonists or siRNA showed impaired fluid shear stress-induced cell alignment, and actin stress fiber formation as early as 6 h. PMID: 27652381
6. There is increased expression of P2Y2 receptors in the rectosigmoid mucosa of diarrhea-predominant irritable bowel syndrome patients. P2Y2 correlated with abdominal pain. PMID: 27250983
7. A novel SNP-systemic lupus erythematosus association was identified between FCHSD2 and P2RY2, peaking at rs11235667 on a 33-kb haplotype upstream of ATG16L2. PMID: 26663301
8. Hypoxia and upregulated HIF-1a both upregulated the P2Y2 levels in hepatocellular carcinoma cells and increased their survival. PMID: 27807254
9. Results show that purinergic receptor P2Y2 (P2Y2R) requires N-glycosylation for expression on the cell surface. PMID: 28209512
10. Data indicate that knockdown of caveolin-1 (Cav-1) expression causes redistribution of the P2Y2 nucleotide receptor (P2Y2R) from membrane rafts. PMID: 27129210
11. The P2RY2 receptor induces carcinoma cell migration and epithelial-mesenchymal transition through cross-talk with EGFR. PMID: 26443721
12. Activation of P2Y2R increased TF promoter activity and mRNA expression in coronary artery endothelial cells. PMID: 26631725
13. Data show that the purinergic receptor P2Y2 (P2Y2R) pepducin activates neutrophils through formyl peptide receptor 2 (FPR2), and ATP is turned into an activating agonist through a receptor cross-talk mechanism that involves both FPR2 and P2Y2R. PMID: 26996596
14. P2Y2 receptor and EGFR cooperate to promote prostate cancer cell invasion via ERK1/2 pathway. PMID: 26182292
15. These results indicate that B2R couples with P2Y2R and that these G-protein-coupled receptors act together to fine-tune cellular responsiveness. PMID: 25713410
16. These results suggest that over-activated ERK and PKC pathways are involved in the P2Y2R-mediated invasion of breast cancer cells. PMID: 26063340
17. P2Y2 and Gq/G11 are required for basal endothelial NO formation, vascular tone, and blood pressure. PMID: 26168216
18. P2Y2R may play an important role in cancer metastasis via modulation of the crosstalk between cancer cells and endothelial cells. PMID: 25156554
19. These results demonstrate that P2Y2R plays an important role in activation of the HIF-1alpha-LOX axis, the induction of collagen crosslinking and the recruitment of CD11b+ hematopoietic bone marrow-derived cells. PMID: 25238333
20. ATP increased P2Y-mediated upregulation of MUC8 expression; however, IL-1alpha significantly decreased the extent to which ATP/P2Y upregulated MUC8 expression. PMID: 25575516
21. Signaling cascades evoked by P2Y2 receptor plays an important role in the phenomena dependent on the actin cytoskeleton dynamics endocy-tosis, cell division, adhesion, intracellular transport and migration.(review) PMID: 25807824
22. P2Y2 receptor fails to repress IL-6 expression by valve interstitial cells through Akt in calcific aortic valve disease. PMID: 24631773
23. The genes CD248, Ephb1 and P2RY2 were detected as the top overexpressed in GC biopsies. PMID: 24716914
24. siRNA against P2Y2R or RAGE, suggesting that P2Y2R is an important mediator in oxLDL-mediated monocyte adhesion to ECs through the regulation of ROS-dependent adhesion molecule expression in ECs. PMID: 24486339
25. P2Y2 receptor deletion in transgenic mice increased Beta-amyloid plaque load and soluble AB1-42 levels in brain from Alzheimer's disease model animals. PMID: 24193664
26. P2Y2R mediated the action of ATP on the cellular behavior of HCC cells through store-operated calcium channel-mediated Ca(2+) signaling PMID: 24847054
27. reflected in the immunoblotting data P2RY2 receptors were detected at higher levels of expression in patient with cortical dysplasia with intractable epilepsy. PMID: 25003238
28. P2Y2 overexpression elevates the inhibitory effect of extracellular ATP on the proliferation of nasopharyngeal carcinoma cells. PMID: 24961145
29. The activation of P2Y2 receptors increases MCF-7 breast cancer cells migration through the MEK-ERK1/2 signalling pathway. PMID: 24390819
30. decrease in Src Y421 and Y446 and paxillin Y118 was detected, indicating the far-reaching importance of the P2Y2 receptor in mediating migration. PMID: 24095926
31. signals generated by the receptor for ATP (P2Y2) reactivate desensitized formyl peptide receptors (FPRs) so that these ligand-bound inactive FPRs resume signaling. PMID: 24491917
32. Results suggest that P2Y2 receptor desensitization protects airways against the deleterious effects of persistent fluid secretion. PMID: 23757023
33. Uridine triphosphate increases proliferation of cancerous pancreatic duct epithelial cells by activation of P2Y2 receptor and PI3K/Akt pathway. PMID: 23462325
34. suggest the P2Y2 receptor and its endothelial downstream signaling mechanisms as a target for antimetastatic therapies PMID: 23810565
35. In women, bone mineral density values at all sites were significantly different between the genotypes for the Leu46Pro polymorphism of the p2y2 receptor PMID: 22773251
36. Activation of P2Y2R and Galphaq by uridine triphosphate promotes hemidesmosome formation. PMID: 22718344
37. IL-8 and IL-6 release after purinergic stimulation in uroepithelial cells is mediated through P2V2 receptors activation. PMID: 23088987
38. Data define the expression profile of P2Y receptors on human biliary epithelial cancer cells and indicate P2Y2 receptors as being potential targets in new treatment strategies for biliary cancer. PMID: 22993317
39. Upon activation by ursolic acid , P2Y2 activated Src which in turn phosphorylated p38 leading to COX-2 overexpression which induced resistance to apoptosis in both colorectal and prostate cancer cells PMID: 22521508
40. Adenosine triphosphate (ATP) enhances proliferation, adhesion, and migration via P2Y2R activation and the immunosuppressive ability of regulatory T (Treg) cells. PMID: 22753942
41. estrogen, via estrogen alpha receptors, promotes proliferation of breast cancer cells by down-regulating purinergic receptor P2Y receptor expression thereby attenuating calcium signaling PMID: 21356271
42. Inhibition of any of the constituents of this cascade (pannexin-1, ATP, P2Y2, and Pyk2) impairs the replication of HIV-1 mutant viruses that are resistant to conventional antiretroviral agents. PMID: 21859844
43. P2Y(2) receptor mediates TF expression in HCAEC through new mechanisms involving Src/p38 and Rho/JNK pathways, possibly contributing to a pro-thrombotic status after vascular injury. PMID: 21652710
44. A P2Y2 isoform represents the predominant purinergic receptor underlying ATP-evoked Ca2+ mobilization, membrane hyperpolarization and de novo synthesis of nitric oxide. PMID: 21414662
45. P2Y(2) R appears to be involved in asthmatic airway inflammation PMID: 20880147
46. Purinergic receptors might represent important new set of molecular targets for theca hyperplasia and polycystic ovarian syndrome. PMID: 20630102
47. Data report that activation of P2Y(2) receptors by extracellular UTP inhibits the IGF-I-induced p110alpha-PI3K activation. PMID: 20089844
48. P2Y2 is the key player in the response of corneal epithelial cells to cell damage and subsequent repair events. PMID: 20427708
49. The rs4944831 and the T-A-G haplotype of the human P2RY2 gene might be genetic markers for essential hypertension in Japanese men. PMID: 19710694
50. These results suggest that P2Y(2)R activation in salivary gland cells promotes the formation of EGFR/ErbB3 heterodimers and metalloprotease-dependent neuregulin 1 release, resulting in the activation of both EGFR and ErbB3. PMID: 20064929

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HGNC: 8541

OMIM: 600041

KEGG: hsa:5029

STRING: 9606.ENSP00000310305

UniGene: Hs.339