Recombinant Human Phosphatidylinositol N-acetylglucosaminyltransferase subunit A(PIGA)

Code CSB-CF017965HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P37287
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Species Homo sapiens (Human)
Source in vitro E.coli expression system
Gene Names PIGA
Protein Names Recommended name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit A EC= Alternative name(s): GlcNAc-PI synthesis protein Phosphatidylinositol-glycan biosynthesis class A protein Short name= PIG-A
Expression Region 1-484
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.
Involvement in disease Paroxysmal nocturnal hemoglobinuria 1 (PNH1); Multiple congenital anomalies-hypotonia-seizures syndrome 2 (MCAHS2)
Subcellular Location Endoplasmic reticulum membrane, Single-pass membrane protein
Protein Families Glycosyltransferase group 1 family, Glycosyltransferase 4 subfamily
Database Links

HGNC: 8957

OMIM: 300818

KEGG: hsa:5277

STRING: 9606.ENSP00000369820

UniGene: Hs.137154

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