Recombinant Human Platelet glycoprotein IX (GP9)

1. Case Report: suggest that alloantibodies directed against Cab4b, the first human platelet antigen carried by glycoprotein IX, can induce severe neonatal thrombocytopenia. PMID: 28561420
2. factor XI is localized to GPIb in membrane rafts and this association is important for promoting the activation of factor XI by thrombin on the platelet surface PMID: 12517745
3. Raft association and cytoskeletal linkage of the platelet GPIb-IX-V complex are interrelated and are required for optimal receptor function, by attracting signaling proteins and membrane skeletal association allows proteins to move to new locations. PMID: 19874464
4. the putative convex surface of the LRR domain in GPIX is sufficient, in the context of full-length subunit, to mediate its association with GPIbbeta PMID: 19566547
5. Novel nonsense mutation is associated with Bernard-Soulier syndrome. PMID: 12447957
6. findings indicate that the Ala14-->Thr mutation in the transmembrane region of GP IX does not induce intracellular GP Ib/IX complex degradation, but prevents its insertion in the cytoplasmic membrane of platelets and CHO cells PMID: 15351858
7. the first non-Caucasian Turkish Bernard-Soulier syndrome case due to GPIX N45S and is likely the result of a recurrent mutational event. PMID: 17804902
8. Findings point to a role of the GPIb-V-IX complex intrinsic to megakaryocytes at the stage of proplatelet formation and suggest a functional link with the underlying microtubular cytoskeleton in platelet biogenesis. PMID: 19377075
9. Homozygous missense mutation in position 1829 (A(R)G) of the GPIX gene causes Bernard-Soulier syndrome in a Swiss family. PMID: 19404517

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HGNC: 4444

OMIM: 173515

KEGG: hsa:2815

STRING: 9606.ENSP00000303942

UniGene: Hs.1144