Recombinant Human Potassium channel subfamily K member 2 (KCNK2)

1. data reveal a druggable K2P site that stabilizes the C-type gate 'leak mode' and provide direct evidence for K2P selectivity filter gating PMID: 28693035
2. decreased TREK-1 expression in the aganglionic and ganglionic bowel observed in Hirschsprung's disease may alter intestinal epithelial barrier function leading to the development of enterocolitis PMID: 27384506
3. Atrial TREK-1 expression was reduced in atrial fibrillation patients with concomitant severe heart failure PMID: 28005193
4. The authors identified a heterozygous point mutation in the selectivity filter of the stretch-activated K2P potassium channel TREK-1 (KCNK2 or K2P2.1). This mutation introduces abnormal sodium permeability and stretch-activation hypersensitivity to TREK-1. PMID: 28242754
5. downregulated in overactive detrusor PMID: 28539337
6. The M2-glycine hinge controls the macroscopic currents of TREK1 channels. PMID: 28676394
7. TREK-1 overexpression suppresses CHO cell proliferation by inhibiting the activity of PKA and p38/MAPK signaling pathways and subsequently inducing G1 phase cell arrest. PMID: 27397543
8. Trek1 expression facilitates the restoration of intestinal epithelial barrier functions in an allergic environment. PMID: 25683610
9. presence of TREK-1 variants correlated to reduced TREK-1 activity, suggesting a pathological role for TREK-1 variants in preterm labor PMID: 26400398
10. Data suggest that potassium channel protein TREK-1 (TREK-1) might be a biomarker in castration resistance free survival (CRFS) judgment of prostate cancer (PCa), as well as a potential therapeutic target. PMID: 25962960
11. During conductance simulation experiments, both TASK-3 and TREK-1 channels were able to repolarise the membrane once AP threshold was reached PMID: 25482670
12. How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2. PMID: 26332952
13. We conclude that Trek1 is critical to maintain the nasal epithelial barrier function. PMID: 25778785
14. Nasal epithelia express Trek1 that can be suppressed by allergic response. PMID: 25529528
15. Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation PMID: 25168769
16. Response of the human detrusor to stretch is regulated by TREK-1 PMID: 24801307
17. PLD2, but not PLD1, directly binds to the C terminus of TREK1 and TREK2. PMID: 25197053
18. results suggest that the TREK-1e splice variant may interfere with the vesicular traffic of full-length TREK-1 channels from the ER to the plasma membrane. PMID: 24196565
19. TREK-1 deficient alveolar epithelial cells have less F-actin and are more deformable making them more resistant to stretch-induced injury. PMID: 24586773
20. Activation of K(2)P channel-TREK1 mediates the neuroprotection induced by sevoflurane preconditioning. PMID: 24154701
21. High TREK-1 expression is associated with epithelial ovarian cancer. PMID: 23479219
22. A number of mutations that affect TREK1 channel gating occlude the action of fenamates but only in the longer form of TREK1. PMID: 24509840
23. In human embryonic kidney (HEK-293) cells stably expressing TREK-1, outward currents at 80 mV increased from 91.0 +/- 23.8 to 247.5 +/- 73.3 pA/pF. PMID: 23804201
24. study analyzed the role of TWIK-related potassium channel-1 (TREK1)in endothelial cells and the blood-brain barrier(BBB); blocking TREK1 increased leukocyte transmigration; TREK1 activation had the opposite effect PMID: 23933981
25. TASK and TREK-1 are involved in regulation of cell proliferation and in control of resting membrane potentials in endometrial epithelial cells. PMID: 23305490
26. we report the expression of Trek-1 in human alveolar epithelial cells and propose that Trek-1 deficiency may alter both IL-6 translation and transcription in AECs without affecting Ca(2+) signaling PMID: 23275623
27. each of four TREK-1 splice variants interacts with full-length wild-type TREK-1 and in vivo, such interactions may contribute to a preterm labor phenotype. PMID: 22811574
28. TREK-1 is expressed by both nucleus pulposus and annulus fibrosus cells of the human intervertebral disc. PMID: 22563662
29. Cochlin interacts with TREK-1 and annexin A2. PMID: 21886777
30. the important role of selectivity filter gating in the regulation of TREK-1 by the extracellular K(+) and proton. PMID: 21965685
31. These results demonstrate that the primary activation mechanisms in TREK-1 reside close to, or within the selectivity filter and do not involve gating at the cytoplasmic bundle crossing. PMID: 21822218
32. The data of this study suggested that TREK-1 is associated with NSC proliferation and probably is a modulator of the effect that fluoxetine attenuates the inhibitory neurogenesis induced by glucocorticoid hormones. PMID: 21069514
33. inhibition of TREK1 current by fluoxetine is found to be accompanied by dissociation of the C-terminal domain from the membrane. PMID: 21262820
34. role for TREK-1 in contributing to uterine quiescence during gestation PMID: 20811500
35. these data suggest that beta-COP plays a critical role in the forward transport of TREK1 channel to the plasma membrane. PMID: 20362547
36. Results describe the regulation of neuronal K(2P)2.1 (KCNK2, TREK-1) channel activity by resting membrane potential. PMID: 19837167
37. These findings indicate that TREK1 genotypes are associated with individual differences in reward-related brain activity. PMID: 19621370
38. TREK-1 channels may function as sensors that couple the metabolic state of the cell to membrane potential, perhaps through an associated ATP-binding protein PMID: 12368289
39. During hypoxia, modulation of hTREK1 cannot be accomplished by parameters known to be perturbed in brain ischemia. hTREK1 regulation in brain will be more relevant during alkalosis than during ischemia or acidosis. PMID: 14522822
40. TREK-1 is inhibited by fluoxetine and norfluoxetine. PMID: 15685212
41. hypoxic inhibition: (a) requires the C-terminal domain of the channel; (b) does not involve redox modulation of the C-terminal domain cysteine residues C365 and C399; and (c) is critically dependent on the glutamate residue at position 306 PMID: 15883010
42. receptor- and kinase-induced inhibition of TREK-1 background potassium channels is mediated by sequential phosphorylation PMID: 16006563
43. human osteoblasts functionally express TREK-1 and that these channels contribute, at least in part, to the resting membrane potential of human osteoblast cells. We hypothesise a possible role for TREK-1 in mechanotransduction, leading to bone remodelling. PMID: 16250016
44. VOCCs and TREK channels have been implicated in mechanotransduction signaling pathways in numerous connective tissue cell types. PMID: 17035301
45. TREK1, the most thoroughly studied K(2P) channel, has a key role in the cellular mechanisms of neuroprotection, anaesthesia, pain and depression--{REVIEW} PMID: 17375039
46. These findings indicate that genetic variation in KCNK2 may identify individuals at risk for treatment resistance. More broadly, they indicate the utility of animal models in identifying genes for pharmacogenetic studies of antidepressant response. PMID: 18288090
47. voltage-dependent C-type gating acceleration by protons represents a novel mechanism for K2P2.1 outward rectification. PMID: 18474599
48. (Review) KCNK2, the gene encoding K2P2.1, can generate either full-length or K2P2.1D1-56 via alternative translation initiation, a mechanism which increases protein diversity by giving rise to two or more proteins from a single mRNA strand. PMID: 18579071
49. Both TASK-3 and TREK-1 are functionally operational in the adrenocortical H295R cell line, modulate membrane potential and aldosterone secretion. PMID: 18854423
50. Results highlight the important role of K(2P)2.1 channels as receptors for mediators known to cause nociception. PMID: 19130888

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HGNC: 6277

OMIM: 603219

KEGG: hsa:3776

STRING: 9606.ENSP00000394033

UniGene: Hs.497745