KCNK2

The protein encoded by KCNK2 is TWIK-related acid-sensitive potassium channel 1 (TASK-1), a member of the two-pore domain potassium (K2P) channel family. Common aliases include K2P2.1. TASK-1 mediates background potassium currents, regulating membrane potential and cellular excitability, particularly in excitable tissues like the heart and brain. It is sensitive to extracellular pH, with decreased activity under acidic conditions.
TASK-1 functions in pathways regulating respiratory drive and cardiac repolarization. Mutations in KCNK2 are linked to familial atrial fibrillation and idiopathic ventricular fibrillation. Pharmacologically, TASK-1 inhibitors are being developed for treating atrial fibrillation by prolonging action potential duration, with several small-molecule antagonists in preclinical evaluation.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

The following KCNK2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

KCNK2 Proteins

KCNK2 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF012070HU(A4)	Recombinant Human Potassium channel subfamily K member 2 (KCNK2)	in vitro E.coli expression system
CSB-YP012070HU	Recombinant Human Potassium channel subfamily K member 2 (KCNK2), partial	Yeast
CSB-EP012070HU CSB-EP012070HU-B	Recombinant Human Potassium channel subfamily K member 2 (KCNK2), partial	E.coli In Vivo Biotinylation in E.coli

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KCNK2

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