Recombinant Human Solute carrier family 2, facilitated glucose transporter member 9(SLC2A9)

Code CSB-CF873638HU(A4)
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Purity Greater than 85% as determined by SDS-PAGE.
Target Names SLC2A9
Uniprot No. Q9NRM0
Research Area Metabolism
Species Homo sapiens (Human)
Source in vitro E.coli expression system
Expression Region 1-540aa
Target Protein Sequence MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYCFLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRP
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 60.2 kDa
Protein Length Full Length
Tag Info N-terminal 10xHis-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA Please contact us to get it.

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Target Background

Function
Urate transporter, which may play a role in the urate reabsorption by proximal tubules. Does not transport glucose, fructose or galactose.
Gene References into Functions
  1. Interaction analysis demonstrated that the following genotypes: MS4A14 DI+II, SLC2A DI+II and ABCB 5 CG+GG, were associated with a prothrombin time >/=12 sec and with Recurrent pregnancy loss (RPL) risk PMID: 29956771
  2. The study identifies the key residues for urate specific transport in human glucose transporter 9. The data data indicate that urate transport in human glucose transporter 9 involves several structural elements rather than just a unique substrate binding pocket. PMID: 28117388
  3. GLUT9 SNPs influence the renal handling of uric acid and modulate serum urate levels and the response to treatment in patients with uric acid overproduction due to Lesch-Nyhan disease. PMID: 29879316
  4. SLC2A9 non-synonymous variants rs2280205 and rs2276961 are not associated with gout in Cameroonians PMID: 29615104
  5. URAT1 and GLUT9 mutations in Spanish patients with renal hypouricemia PMID: 29486147
  6. SLC2A9/GLUT9 rs1172228 CC genotype in gout had significant associations with higher levels of serum uric acid, renal calculi and a positive family history of gout. PMID: 27456670
  7. Combined exposure to the four high-risk genotypes of ALPK1 and the uric-acid-related loci of ABCG2, SLC2A9, and SLC22A12 was associated with an increased gout risk and a high PPV for gout. PMID: 29215084
  8. This study demonstrated that reduced glucose transporter-1 in brain derived circulating endothelial cells in mild Alzheimer's disease patients. PMID: 29102777
  9. Immunoreactivity of GLUT9 was observed on the apical side of the cytoplasm of epithelial cells in the choroid plexus and in the cilia of ependymal cells of the human brain. PMID: 28870626
  10. genetic association studies in population in China: Data suggest that SNPs in SLC2A9 (rs11722228, rs3775948) and ABCG2 (rs2231142) are associated with diabetic kidney disease in subjects with type 2 diabetes in the population studied. (SLC2A9 = solute carrier family 2 member 9; ABCG2 = ATP binding cassette subfamily G member 2) PMID: 26993665
  11. This meta-analysis shows that the rs12510549, rs16890979, and rs1014290 polymorphisms of SLC2A9 protect against the development of gout in Caucasians and/or Asians. PMID: 27052299
  12. The results of the study confirmed the presence of GLUT-1, GLUT-4 and GLUT-9 proteins in the trophoblast from both, uncomplicated and diabetic pregnancies. In addition, insulin therapy may increase placental expression of GLUT-4 and GLUT-9, and partially GLUT-1, in women with pregestational and gestational diabetes mellitus. PMID: 27981520
  13. Meta-analysis. This study demonstrated that the genetic susceptibility for gout is associated with the SLC2A9 gene polymorphisms. Four of them except for the rs3733591 are protective SNPs in Caucasians, and rs16890979 and rs1014290 are protective SNPs in both Caucasians and Asians, while rs3733591 may be susceptibility SNP in Asians. PMID: 27255295
  14. Each A-allele of the SLC2A9 rs7442295 was associated with 9% higher plasma urate and hazard ratios of 1.07 (1.01-1.14) for cancer incidence and 1.07 (1.02-1.13) for all-cause mortality. PMID: 28428355
  15. The present proof-of-principle paper demonstrates that the multilocus profiles of ABCG2, SLC2A9 and SLC22A12 increase susceptibility to asymptomatic hyperuricaemia, gout and tophi. PMID: 27225847
  16. variant p.G72D associated with renal hypouricemia type 2 PMID: 26500098
  17. Immunostaining and highly-sensitive in situ hybridization was used to assess the distribution of UA transporters: GLUT9/URATv1, ABCG2, and URAT1. Immunostaining for GLUT9 was observed in ependymal cells, neurons, and brain capillaries. Immunostaining for ABCG2 was observed in the choroid plexus epithelium and brain capillaries, but not in ependymal cells. These results were validated by in situ hybridization. PMID: 27955673
  18. the exon 9 of SLC2A9 gene 109C/T polymorphism is not associated with HUA and diabetes PMID: 25476142
  19. Demonstrate a significant association between rs2231142 in the ABCG2 gene and gout and identified novel SNPs, c.881A>G and c.1002+78G>A, in the SLC2A9 gene that may be associated with gout in a Korean population. PMID: 26552468
  20. GLUT9 gene polymorphism predicts higher risk for cardiovascular diseases in patient diagnosed with hyperuricemia. PMID: 26607700
  21. These results indicate that five newly described SNPs in the hURAT1 gene are significantly associated with uric acid level (4-2008-0318 and 4-2011-0277). PMID: 26603249
  22. SLC2A9 was associated with a decreased risk of gout in men (HR = 0.67, 95% CI: 0.49-0.91) and women (HR = 0.54, 95% CI: 0.33-0.89. PMID: 26714568
  23. SLC2A9 and ZNF518B polymorphisms correlate with gout-related metabolic indices in Chinese Tibetan populations PMID: 26345926
  24. single nucleotide polymorphisms in the SLC2A9 gene influence SLC2A9 gene expression as well as urinary uric acid excretion. PMID: 26167684
  25. The SLC2A9 (rs7660895) and TOX (rs11777927) gene polymorphisms may be associated with formation of intracranial aneurysms, and rs7660895 may be associated with intracranial aneurysms rupture. PMID: 26125895
  26. Case Report: homozygous splice-site mutation in the SLC2A9 gene resulting in renal hypouricemia and recurrent exercise-induced acute renal failure and posterior reversible encephalopathy syndrome. PMID: 24643436
  27. SLC2A9 genetic mutation is involved in renal excretion of uric acid. PMID: 25889045
  28. Polymorphism in the GLUT9 gene, a major genetic regulator of serum uric acid levels, interacts with asymmetric dimethylarginine levels in predicting renal disease progression in chronic renal insufficiency patients. PMID: 25435339
  29. Case-control study with 1,146 coronary heart disease (CHD) Chinese cases; association between 2 uric acid related SNP rs11722228 in SLC2A9 and rs4148152 in ABCG2 and CHD risk analyzed; no association was observed between rs11722228 and CHD risk; Among subjects who did not consume alcohol, the G allele of rs4148152 showed a moderate protective effect. PMID: 25634581
  30. advances our understanding of how hSLC2A9 mediates urate and fructose transport, providing further information for developing pharmacological agents to treat hyperuricemia and related diseases, such as gout, hypertension, and diabetes PMID: 25922070
  31. protein expression of URAT1 and GLUT9 in renal tissues of patients with uric acid (UA) nephrolithiasis PMID: 24723238
  32. GLUT9 rs734553 polymorphism, which is strongly associated with serum uric acid levels in healthy individuals of the general population with normal renal function, holds a strong predictive power for chronic kidney disease progression. PMID: 24742479
  33. Single-nucleotide polymorphisms (SNP) rs2231137(C9T) and rs2231142 (C9A) of ABCG2 were found in this familial aggregation of Chinese female premenopausal gout. PMID: 25275768
  34. SLC2A9 SNPs are associated with serum uric acid levels in Chinese males and females. PMID: 25283508
  35. The surface expression, purification and isolation of monomeric protein, and functional analysis of recombinant hGLUT9, is reported. PMID: 25286413
  36. Genetic polymorphisms in the urate transporters SLC2A9, SLC22A12 and non-synonymous allelic variants of GLUT9 showed no evidence of the effect on hyperuricemia and gout in the Czech population. PMID: 25268603
  37. the p53-SLC2A9 pathway is a novel antioxidant mechanism that uses uric acid to maintain reactive oxygen species homeostasis and prevent accumulation of reactive oxygen species-associated damage that potentially contributes to cancer development. PMID: 24858040
  38. genetic variation in SLC2A9 is associated with serum uric acid concentrations, an important biomarker of renal and cardiovascular disease risk, in Hispanic children PMID: 25833971
  39. Gout with uric acid underexcretion is associated with transporter gene SNP related mainly to tubular reabsorption, whereas uric acid normoexcretion is associated only with tubular secretion SNP. PMID: 25128519
  40. Abundant local interactions in the 4p16.1 region suggest functional mechanisms underlying SLC2A9 associations with human serum uric acid. PMID: 24821702
  41. Placental GLUT-9 expression was not correlated with birthweight. PMID: 25132463
  42. tested the association between uric acid, the rs734555 polymorphism of the GLUT9 gene and arterial pressure in a family-based study including 449 individuals in a genetically homogenous population in Southern Italy PMID: 24805955
  43. Serum uric acid level was dose-dependently associated with the T allele of rs734553, a polymorphism in SLC2A9. PMID: 25301104
  44. hypouricemia patient with GLUT9 R380W, a pathogenic mutation of renal hypouricemia type 2 PMID: 24940677
  45. A strong association was found between SLC2A9 gene polymorphisms and SUA in all centers combined (P-values: 1.3 x 10(-31)-5.1 x 10(-23)) and also when stratified by recruitment center; P-values: 1.2 x 10(-14)-1.0 x 10(-5). PMID: 24301058
  46. ERbeta may affect the expression of Glut9 though autophagy PMID: 24972010
  47. The hazard ratio for progression to disability in Parkinson's disease patients increased with increasing SLCA9 score. PMID: 25257975
  48. When maternal environmental tobacco smoke was considered, fifteen of 135 single nucleotide polymorphism (SNPs) mapping to SLC2A9 and 9 of 59 SNPs in WDR1 gave P values approaching genome-wide significance. PMID: 24516586
  49. data suggest that nuclear receptor family member HNF4alpha contributes to the transcriptional regulation of SLC2A9 isoform 1 PMID: 25209865
  50. The gene-environment interaction data suggest that SLC2A9-mediated renal uric acid excretion is influenced by intake of simple sugars derived from sugar-sweetened beverages (SSB), with SSB exposure negating the gout risk discrimination of SLC2A9. PMID: 24026676

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Involvement in disease Hypouricemia renal 2 (RHUC2)
Subcellular Location [Isoform 1]: Basolateral cell membrane; Multi-pass membrane protein.; [Isoform 2]: Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Protein Families Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family, Glucose transporter subfamily
Tissue Specificity Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver and placenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular cartilage. Isoform 2 is only detected in the apical membra
Database Links

HGNC: 13446

OMIM: 606142

KEGG: hsa:56606

STRING: 9606.ENSP00000264784

UniGene: Hs.444612

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