Recombinant Human Uroplakin-1b (UPK1B)

Code CSB-CF025655HU
MSDS
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names
UPK1B
Uniprot No.
Alternative Names
UPK1B; TSPAN2; Uroplakin-1b; UP1b; Tetraspanin-20; Tspan-20; Uroplakin Ib; UPIb
Species
Homo sapiens (Human)
Expression Region
1-260
Target Protein Sequence
AKDNSTVRCFQGLLIFGNVIIGCCGIALTAECIFFVSDQHSLYPLLEATDNDDIYGAAWI GIFVGICLFCLSVLGIVGIMKSSRKILLAYFILMFIVYAFEVASCITAATQQDFFTPNLF LKQMLERYQNNSPPNNDDQWKNNGVTKTWDRLMLQDNCCGVNGPSDWQKYTSAFRTENND ADYPWPRQCCVMNNLKEPLNLEACKLGVPGFYHNQGCYELISGPMNRHAWGVAWFGFAIL CWTFWVLLGTMFYWSRIEY
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Protein Length
Full Length
Tag Info
N-terminal 10xHis-tagged
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer
Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.

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Target Background

Function
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.
Gene References into Functions
  1. Urine UPIb levels may be useful for predicting the risk of recurrent urinary tract infections in patients diagnosed with their first UTI and may also be considered as a noninvasive screening test for vesicoureteral reflux. PMID: 24559587
  2. established the genomic organization of the UPIb gene PMID: 12031497
  3. Loss of uroplakin Ib expression is associated with bladder carcinomas PMID: 15140401
  4. Loss of uroplakin Ib expression by CpG methylation of Sp1/NFkappaB-binding motifs within the proximal promoter is associated with urothelial tumors PMID: 16354592
  5. The biopsy-induced increase in the expression of UPIb and other genes encoding membrane proteins supports the possible importance of the membrane structure and stability during implantation. PMID: 18355812

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Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
Tetraspanin (TM4SF) family
Tissue Specificity
Bladder epithelium.
Database Links

HGNC: 12578

OMIM: 602380

KEGG: hsa:7348

STRING: 9606.ENSP00000264234

UniGene: Hs.271580

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